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概要 | The wiring mechanisms of a cortical interneuron subtype |
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日時 | 2021年12月21日火曜日・9:00~10:30 |
場所 | Zoomによるオンライン開催 |
講師 | Hiroki Taniguchi, Ph.D.(The Ohio State University (OSU) Wexner Medical Center) |
連絡先 | 小坂田文隆(fosakada@ps.nagoya-u.ac.jp/6814) |
ファイル | 1639565818147SouyakuSeminar_HirokiTaniguchi.pdf |
Abstract:
Cortical inhibitory interneurons (INs) play a pivotal role in balancing/shaping brain activity. Their malformation and malfunction have been implicated in a variety of brain disorders such as epilepsy, schizophrenia, and autism. Despite their functional significance, the wiring principle of IN circuits remains largely unknown. Cortical INs comprise diverse neuronal subtypes, each of which establishes specific local circuits and mediates a unique inhibitory function, and therefore need to be dissected in a cell-type specific manner. Taking advantage of genetic approaches that enable a cell-type specific dissection, we have explored the molecular/cellular mechanisms underlying the assembly of IN circuits. In this presentation, I will talk about two major developmental events that are critical for building IN circuits: axonal branching and synaptic specificity. I will demonstrate 1) Acetylcholine regulates axonal arborization of a cortical IN subtype and 2) IgSF11, a homophilic cell adhesion molecule, dictates laminar synaptic specificity of a cortical IN subtype. We hope the outcome from our research will provide the basis for reconstructing functional neuronal circuits in the damaged/diseased brain.
Cortical inhibitory interneurons (INs) play a pivotal role in balancing/shaping brain activity. Their malformation and malfunction have been implicated in a variety of brain disorders such as epilepsy, schizophrenia, and autism. Despite their functional significance, the wiring principle of IN circuits remains largely unknown. Cortical INs comprise diverse neuronal subtypes, each of which establishes specific local circuits and mediates a unique inhibitory function, and therefore need to be dissected in a cell-type specific manner. Taking advantage of genetic approaches that enable a cell-type specific dissection, we have explored the molecular/cellular mechanisms underlying the assembly of IN circuits. In this presentation, I will talk about two major developmental events that are critical for building IN circuits: axonal branching and synaptic specificity. I will demonstrate 1) Acetylcholine regulates axonal arborization of a cortical IN subtype and 2) IgSF11, a homophilic cell adhesion molecule, dictates laminar synaptic specificity of a cortical IN subtype. We hope the outcome from our research will provide the basis for reconstructing functional neuronal circuits in the damaged/diseased brain.