下記の通り創薬科学セミナーを開催します。多数のご参加をお待ちしております。申し込みURLよりお申込みをお願いします。
概要 | LPSを足場としたセリンプロテアーゼ前駆体の活性型遷移状態を介した自己触媒的活性化の分子機構 |
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日時 | 2022年11月08日火曜日・14:00-15:30 |
場所 | 創薬科学研究館 講義室 Zoomを並行実施 |
場所(URL) | https://docs.google.com/forms/d/e/1FAIpQLSchXUXAHgq6IXuo7blZ5Q3vqkaX3ngskF-qLVzawiA5U80rzA/viewform?usp=sf_link |
講師 | 川畑俊一郎(九州大学大学院 理学研究院/教授) |
連絡先 | 人見清隆(hitomi@ps.nagoya-u.ac.jp) |
ファイル | 16654533811108創薬セミナー案内人見清隆.pdf |
血液凝固系に代表される複数の酵素前駆体からなる活性化の連鎖反応では、最上流の前駆体の活性化は前駆体どうしの分子間相互作用を介する自己触媒的活性化で説明される。しかし、その概念を支える分子機構の実態は推測の域を出ていない。本講演では、グラム陰性菌のリポ多糖(LPS)を反応の足場として自己触媒的活性化を引き起こすカブトガニ体液凝固系のセリンプロテアーゼ前駆体を取り上げ、自己触媒的活性化を解説頂く。
The chain reaction of activation consisting of multiple enzyme precursors, called cascade reaction, has been widely recognized as an important biological defense system, which was first reported for the mammalian blood coagulation system in 1964. The activation of the most upstream precursor in the cascade is explained as an autocatalytic activation mediated by the intermolecular interaction between precursors (proximity effect). However, the actual molecular mechanism underlying this concept remains a matter of speculation. In this talk, I will focus on one of serine protease precursors involved in the hemolymph coagulation system of horseshoe crabs, which is autocatalytically activated on the surface of lipopolysaccharide (LPS) of Gram-negative bacteria.
The chain reaction of activation consisting of multiple enzyme precursors, called cascade reaction, has been widely recognized as an important biological defense system, which was first reported for the mammalian blood coagulation system in 1964. The activation of the most upstream precursor in the cascade is explained as an autocatalytic activation mediated by the intermolecular interaction between precursors (proximity effect). However, the actual molecular mechanism underlying this concept remains a matter of speculation. In this talk, I will focus on one of serine protease precursors involved in the hemolymph coagulation system of horseshoe crabs, which is autocatalytically activated on the surface of lipopolysaccharide (LPS) of Gram-negative bacteria.