創薬科学研究科主催 第72回創薬科学セミナー
本セミナーは、先端薬科学特論・単位認定セミナーです。
概要 | Imaging the Mouse Visual System: Parallel Pathways and Visual Cortical Areas |
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日時 | 2017年10月30日月曜日・15:00~16:30 |
場所 | 創薬科学研究館 2階 講義室(205) |
講師 | Edward M. Callaway博士(Systems Neurobiology Laboratory, Salk Institute for Biological Studies (USA)) |
連絡先 | 小坂田 文隆(6814) |
ファイル | 1508737087第72回創薬科学セミナー.pdf |
To understand the mechanisms by which neural circuits process information, it is necessary to resolve
connectivity with high resolution, to correlate connectivity with function, and to manipulate the activity
of defined circuit components. Until recently, most efforts to understand the neural mechanisms
underlying visual perception have taken advantage of the organization of the primate visual system
into functionally specialized areas and modules. This work effectively described neural substrates and
their interactions at these levels of resolution. But our in vitro studies of cortical circuits demonstrated
that local microcircuits are selective at finer levels of resolution - cell types and single neurons. It is
therefore clear that in order to understand how cortical microcircuits compute visual information one
must either develop new approaches in primates or study mice, in which recent advances in the
development of molecular, genetic and viral based tools allow cell-type specific regulation of gene
expression. We have therefore conducted foundational studies to understand the basic functional
organization of the mouse visual system.
connectivity with high resolution, to correlate connectivity with function, and to manipulate the activity
of defined circuit components. Until recently, most efforts to understand the neural mechanisms
underlying visual perception have taken advantage of the organization of the primate visual system
into functionally specialized areas and modules. This work effectively described neural substrates and
their interactions at these levels of resolution. But our in vitro studies of cortical circuits demonstrated
that local microcircuits are selective at finer levels of resolution - cell types and single neurons. It is
therefore clear that in order to understand how cortical microcircuits compute visual information one
must either develop new approaches in primates or study mice, in which recent advances in the
development of molecular, genetic and viral based tools allow cell-type specific regulation of gene
expression. We have therefore conducted foundational studies to understand the basic functional
organization of the mouse visual system.