第91回創薬科学セミナー
本セミナーは、先端薬科学特論・単位認定セミナーとして認められています。
概要 | The cerebellum and arousal(小脳と覚醒) |
---|---|
日時 | 2018年12月10日月曜日・15:00~16:30 |
場所 | 創薬科学研究館 2階 講義室(205) |
講師 | Takashi Kodama, Ph.D. (児玉 貴史 博士)(Johns Hopkins University School of Medicine(ジョンズホプキンス大学 医学部)) |
連絡先 | 小坂田 文隆(6814) |
ファイル | 1543277004創薬科学セミナーポスターTakashiKodama.pdf |
Damage to the cerebellum impairs coordination of movements in many cases, which is so conspicuous that the cerebellum has been regarded as a part of motor system for centuries. Recent studies, however, suggest that the cerebellum is more than a motor coordinator. Cognitive and affective functions are impaired in patients with lesions involving the posterior lobe and the vermis of the cerebellum. Multiple major psychiatric disorders such as autism and schizophrenia are also associated with abnormal size or activities of these portions of the cerebellum. However, in spite of the accumulating implications from functional imaging and clinical studies, it has been poorly understood HOW the cerebellum engages non-motor functions. To tackle the question, we combined neural tracing, optogenetic manipulation, electrophysiology, and behavioral assays in mice, and revealed that the posterior vermis of the cerebellum directly connects with the arousal system widely distributing from the thalamus to the brainstem, powerfully initiating startle and arousal responses. In the seminar, quick overviews of cerebellar research, the arousal system, and experiment techniques will be also presented for graduate students.
(セミナーは日本語で行います。)
(セミナーは日本語で行います。)