| Laboratory | Members | Education, Research and Objectives |
|---|---|---|
| Laboratory of Structural Molecular Pharmacology SITE |
Professor : Hidekazu Hiroaki Associate Professor : Tetsuya Kodama Assistant Professor : Emi Hibino |
In order to understand the mechanism(s) of action of drugs and proteins, their three-dimensional structures and intermolecular interactions should be quantitatively evaluated. In turn, such studies can enable the rapid and rational design of novel drugs. This laboratory implements research and education in molecular pharmacology based on the three-dimensional structure of drugs, following the process from structural biology to drug development with special consideration for new generation drugs (e.g., antibodies and nucleic acids). With respect to methodologies, we primarily use nuclear magnetic resonance in combination with X-ray crystallography. |
| Laboratory of Structural Physiology SITE |
Professor : Atsunori Oshima |
Membrane proteins residing in the plasma membrane account for a large proportion of drug development targets. In our laboratory, we conduct research and education in the development of basic technologies, including electron crystallography that enables the structural analysis of membrane proteins within their natural environment of lipid membranes. We also investigate the structures of membrane proteins considered to be highly significant as drug development targets. |
