| Job title |
Professor |
| Laboratory |
Laboratory of Structural Physiology(Cellular and Structural Physiology Institute) |
| Room |
Pharmaceutical Sciences Building, Room 208 |
| Outside line |
+81-52-747-6837 |
| Fields of research |
Structural Biology, Gap junction channel, Electron Microscopy |
Outline of research
Most multicellular organisms, such as vertebrates and invertebrates, possess gap junctions comprising clusters of channels that mediate the direct communication between adjacent cells. High-resolution structures of gap junction channels are investigated using cryo-electron microscopy (cryo-EM) to elucidate the molecular basis of the gating mechanism and the biologic significance in vivo. We are also focusing on optimizing the sample preparation for cryo-EM, such as the nanodisc reconstruction method for structural analysis of membrane proteins in lipid bilayer.
