論文リスト


2024 2023 2022 2021 2020 2019 2018 2017 2016 2015
2014 2013 2012 2011 2010 2009 2008 2007
2006 2004 2003 2002 2001 2000 1998


2024


Total Synthesis of Putative Melognine


Yui Irie and Satoshi Yokoshima
J. Am. Chem. Soc., 146, 9526 (2024)
(doi: 10.1021/jacs.4c02086)



2023


Deep learning driven de novo drug design based on gastric proton pump structures


Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Nariyoshi Umekubo, Satoshi Yokoshima & Atsushi Yoshimori
Commun. Biol., 6, 956 (2023)
(doi: 10.1038/s42003-023-05334-8)
Press Release (2023.9.29)


Total syntheses of macleanine and lycoposerramine-S


Masahiro Okuyama, Nariyoshi Umekubo, Kenta Akimoto, Takahisa Shimizu, Kazuhiro Kubokoya, Nagayasu Nakajima, Yoshitake Nishiyama and Satoshi Yokoshima
Org. Biomol. Chem., 21, 6289 (2023)
(doi: 10.1039/D3OB01065A)


Total Synthesis of Malettinins C and E


Nariyoshi Umekubo and Satoshi Yokoshima
Org. Lett., 25, 4530 (2023)
(doi: 10.1021/acs.orglett.3c00838)
This work was selected as the most read articles on a monthly basis.
This work was selected on SYNFACTS of the month
This work was cited in Org. Chem. Highlights

Construction of the tetracyclic ring system of diterpene alkaloids via cationic [5 + 2] cycloaddition


Kosuke Mizuno, Yoshitake Nishiyama and Satoshi Yokoshima
Org. Biomol. Chem., 21, 4587 (2023)
(doi: 10.1039/d3ob00647f)


Total Synthesis of Kopsone


Kazutoshi Tomoya, Kazuaki Komiya, Daisuke Nakajima, Nariyoshi Umekubo, and Satoshi Yokoshima
Org. Lett., 25, 2718 (2023)
(doi: 10.1021/acs.orglett.3c00838)
This work was selected as the most read articles on a monthly basis
This work was cited in Org. Chem. Highlights

Fluorinated 2,6-Xylenesulfonyl Group: A Protective Group for Amines


Yuki Katayama, Kenta Watanabe, Yoshitake Nishiyama, and Satoshi Yokoshima
Org. Lett., 25, 1326 (2023)
(doi: 10.1021/acs.orglett.3c00299)


Convergent synthesis of the [5-7-6-3] tetracyclic core of premyrsinane diterpenes


Kohei Yoshinaga and Satoshi Yokoshima
Org. Biomol. Chem., 21, 724 (2023)
(doi: 10.1039/d2ob02210a)



2022


Construction of the [7–5–5] Tricyclic Core of Daphniphyllum Alkaloids via a Cationic Cascade Reaction


Daisuke Nakajima and Satoshi Yokoshima
Org. Lett., 24, 9520 (2022)
(doi: 10.1021/acs.orglett.2c04023)


Formal Synthesis of Ecteinascidin 743 via an Intramolecular Cascade Heck Reaction to Construct the Diazabicyclo[3.3.1]nonane Framework


Nagayasu Nakajima, Eiji Yoshida, Tatsuya Toma, Yoshitake Nishiyama, Masayuki Inoue, Tohru Fukuyama, and Satoshi Yokoshima
Org. Lett., 24, 8228 (2022)
(doi: 10.1021/acs.orglett.2c03357)


Substitution of α-Azido Sulfones with Thiolates to Form α-Azido Sulfides


Akito Katayama, Yuan Jin, Yoshitake Nishiyama, Takamitsu Hosoya, and Satoshi Yokoshima
Org. Lett., 24, 7361 (2022)
(doi: 10.1021/acs.orglett.2c02895)


Photoinduced Rearrangement of α-(2-Nitrophenyl)ketones


Shinnosuke Kitayama, Hiroaki Shimizu, and Satoshi Yokoshima
Org. Biomol. Chem., 20, 7896 (2022)
(doi: 10.1039/D2OB01546C)


Anticancer Approach Inspired by the Hepatotoxic Mechanism of Pyrrolizidine Alkaloids with Glycosylated Artificial Metalloenzymes


Michitaka Kurimoto, Tsung-che Chang, Yoshitake Nishiyama, Takehiro Suzuki, Naoshi Dohmae, Katsunori Tanaka, Satoshi Yokoshima
Angew. Chem. Int. Ed., 2022, 61, e2202205541
(doi: 10.1002/anie.202205541)
Press Release (2022.9.29)
This work was highlighted as a Spotlight Research in Chem-Station.
This work was introduced as an article of FOCUS in Newton (2023.1).


Synthetic Approach toward (-)-Tetrodotoxin via Construction of the Bicyclo[2.2.2]octane Skeleton


Kazuki Kobayashi, Yoshiki Senoo, Tatuya Toma, Tohru Fukuyama, Satoshi Yokoshima
Synlett, 33, 391 (2022)
(doi: 10.1055/s-0041-1737803)



2021


Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer’s disease mice


Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi, Takanobu Suzuki, Wenbo Wang, Yung Wen Chiu, Reiko Koike, Satoshi Yokoshima, Tohru Fukuyama, Sho Takatori, Youhei Sohma, Motomu Kanai, Taisuke Tomita
Brain, 144, 1884 (2021)
(doi: 10.1093/brain/awab058/6224831)


Nitrone Formation by Reaction of an Enolate with a Nitro Group



Hiroaki Shimizu, Kohei Yoshinaga, and Satoshi Yokoshima
Org. Lett., 23, 2704 (2021)
(doi: 10.1021/acs.orglett.1c00603)


Copper-Mediated Conversion of Alkynes into Nitriles via Iodotriazoles



Ryosuke Kori, Keigo Murakami, Yoshitake Nishiyama, Tatsuya Toma, Satoshi Yokoshima
Chem. Pharm. Bull., 69, 278 (2021)
(doi: 10.1248/cpb.c20-00787)


Total Synthesis of Haliclonin A



Yuan Jin, Kensuke Orihara, Fumiki Kawagishi, Tatsuya Toma, Tohru Fukuyama, Satoshi Yokoshima
Angew. Chem. Int. Ed., 60, 9666 (2021)
(doi: 10.1002/anie.202016343)
One of the most downloaded papers during the first 12 months of publication in Angewandte Chemie International Edition


A novel translation inhibitor, mersicarpine, inhibits S-phase progression and induces apoptosis in HL60 cells


Tomoko Shiobara, Yoko Nagumo, Rie Nakajima, Tohru Fukuyama, Satoshi Yokoshima, Takeo Usui
Bioscience, Biotechnology, and Biochemistry, 85, 92 (2021)
(doi: 10.1093/bbb/zbaa070)


Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids


Satoshi Yokoshima
Chem. Lett., 50, 96 (2021)
(doi: 10.1246/cl.200695)



2020


Structure–Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity


Noriyuki Natsume, Kaori Ozaki, Daisuke Nakajima, Satoshi Yokoshima, Toshiaki Teruya
J. Nat. Prod., 83, 2477 (2020)
(doi: 10.1021/acs.jnatprod.0c00441)


Synthesis of Polycyclic Natural Products through Skeletal Rearrangement


Satoshi Yokoshima
Synlett, 31, 1967 (2020)
(doi: 10.1055/s-0040-1707904)


Synthetic Studies on Densanins: Stereoselective Construction of a Pyrrolidine Ring Containing a Quaternary Carbon


Kyosuke Ueda and Satoshi Yokoshima
Heterocycles, 103, 172 (2021)
(doi: 10.3987/COM-20-S(K)4)


Semipinacol Rearrangement Induced by Cleavage of Dibromocyclopropane



Michitaka Kurimoto, Daisuke Nakajima, Yoshitake Nishiyama, Satoshi Yokoshima
Eur. J. Org. Chem., 4108 (2020)
(doi: 10.1055/s-0037-1611805)
This article was selected as a Front Cover.


Total Synthesis of Tetrodotoxin



Keigo Murakami, Tatsuya Toma, Tohru Fukuyama, Satoshi Yokoshima
Angew. Chem. Int. Ed., 59, 6253 (2020)
(doi: 10.1002/anie.201916611)
This paper was selected as newsworthy by the editorial office.
This paper was featured on Synfacts.


Synthetic Studies on Bilobalide



Akihiro Shiogai, Tatsuya Toma, Satoshi Yokoshima
Synlett, 31, 290 (2020)
(doi: 10.1055/s-0037-1611805)



2019


An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves


Kenward Vong, Shohei Eda, Yasuhiro Kadota, Igor Nasibullin, Takanori Wakatake, Satoshi Yokoshima, Ken Shirasu, Katsunori Tanaka
Nat. Commun., 10, 5746 (2019)
(doi: 10.1038/s41467-019-13758-2)


Synthesis of Majusculamides A and B



Daisuke Nakajima, Kosuke Sueyoshi, Kensuke Orihara, Toshiaki Teruya, Satoshi Yokoshima
Synlett, 30, 924 (2019)
(doi: 10.1055/s-0037-1611805)


Synthetic Studies of Isoschizogamine: Alternative Preparation of the Key Intermediate



Noriyuki Hayashi, Yusuke Miura, Satoshi Yokoshima, Tohru Fukuyama
Chem. Pharm. Bull., 67, 64 (2019)
(doi: 10.1248/cpb.c18-00718)



2018


Total Synthesis of Lycoposerramine-R


Shinya Watanabe, Masatsugu Ishikawa, Toshimune Nomura, Tohru Fukuyama, Satoshi Yokoshima
Synlett, 29, 2377 (2018)
(doi: 10.1055/s-0037-1611024)


Synthetic Studies of the Daphniphyllum Alkaloids: A Cooperative Reaction of Proximal Functional Groups Forming a Tetracyclic System


Ryosuke Yamada, Tohru Fukuyama, Satoshi Yokoshima
Org. Lett., 20, 4504 (2018)
(doi: 10.1021/acs.orglett.8b01800)


A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model


Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Nat. Commun., 9, 2668 (2018)
(doi: 10.1038/s41467-018-05127-2)


Synthesis of the [7-5-5] Tricyclic Core of Daphniphyllum Alkaloids



Yusuke Kitabayashi, Tohru Fukuyama, Satoshi Yokoshima
Org. Biomol. Chem., 16, 3556 (2018)
(doi: 10.1039/C8OB00859K)


Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring


Kensuke Orihara, Fumiki Kawagishi, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 29, 769 (2018)
(doi: 10.1055/s-0037-1609150)


Total Synthesis of Huperzine R


Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 20, 119 (2018)
(doi: 10.1021/acs.orglett.7b03555)


Total Synthesis of (+)-lysergic acid


Rentaro Kanno, Satoshi Yokoshima, Motomu Kanai, Tohru Fukuyama
The Jornal of Antibiotics, 71, 240 (2018)
(doi: 10.1038/ja.2017.80)



2017


Synthesis of Cardiopetaline via a Wagner–Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group


Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 19, 5833 (2017)
(doi: 10.1021/acs.orglett.7b02812)


Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

Yoshihiro Usui, Fumiaki Uehara, Shinsuke Hiki, Kazutoshi Watanabe, Hiroshi Tanaka, Aya Shouda, Satoshi Yokoshima, Keiichi Aritomo, Takashi Adachi, Kenji Fukunaga, Shinji Sunada, Mika Nabeno, Ken-Ichi Saito, Jun-ichi Eguchi, Keiji Yamagami, Shouichi Asano, Shinji Tanaka, Satoshi Yuki, Narihiko Yoshii, Masatake Fujimura, Takashi Horikawa
Bioorganic & Medicinal Chemistry Letters, 27, 3726 (2017)
(doi: 10.1016/j.bmcl.2017.06.078)


Total Synthesis of Huperzine Q


Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 19, 3684 (2017)
(doi: 10.1021/acs.orglett.7b01633)


High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano
Scientific Reports, 7, 4029 (2017)
(doi: 10.1038/s41598-017-03567-2)


Total Syntheses of Aurachins A and B


Haruhiko Hattori, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 56, 6980 (2017)
(doi: 10.1002/anie.201702204)


Total Synthesis of (−)-Morphine


Hirotatsu Umihara, Satoshi Yokoshima, Masayuki Inoue, Tohru Fukuyama
Chem. Eur. J., 23, 6993 (2017)
(doi: 10.1002/chem.201701438)


Total Synthesis of (−)-Tetrodotoxin and 11-norTTX-6(R)-ol


Tomoaki Maehara, Keisuke Motoyama, Tatsuya Toma, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 56, 1549 (2017)
(doi: 10.1002/anie.201611574)
This paper was selected as a Hot Paper.

Total Synthesis of Lycopalhine A


Yuji Ochi, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 49, 96 (2017)
(doi: 10.1055/s-0036-1588878)



2016


Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules


Satoshi Yokoshima, Masatsugu Ishikawa, Youko Beniyama, Tohru Fukuyama
Chem. Phaem. Bull, 64, 1528 (2016)
(doi: 10/64_c16-00507)


Conversion of Vindoline into 11-Mesyloxytabersonine


Yuki Han-ya, Tomohiko Inui, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
Chem. Pharm. Bull., 64, 800 (2016)
(doi: 10.1248/cpb.c16-00175)


Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation


Yu Ota, Takumi Chinen, Keisuke Yoshida, Shun Kudo, Yoko Nagumo, Yuh Shiwa, Ryosuke Yamada, Hirotatsu Umihara, Kotaro Iwasaki, Hiroshi Masumoto, Satoshi Yokoshima, Hirofumi Yoshikawa, Tohru Fukuyama, Junichi Kobayashi, Takeo Usui
ChemBioChem, 17, 1616 (2016)
(doi: 10.1002/cbic.201600075/abstract)


BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

Toji Miyagawa, Ihori Ebinuma, Yuichi Morohashi, Yukiko Hori, Mee Young Chang, Haruhiko Hattori, Tomoaki Maehara, Satoshi Yokoshima, Tohru Fukuyama, Shoji Tsuji, Takeshi Iwatsubo, George C. Prendergast, Taisuke Tomita
HUMAN MOLECULAR GENETICS, 25, 2948 (2016)
(doi: 10.1093/hmg/ddw146)


Total Synthesis of (−)-Cardiopetaline


Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 18, 2359 (2016)
(doi: 10.1021/acs.orglett.6b00789)


Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B

Shun Kawai, Hiroto Sasaki, Norihiro Okada, Kei Kanie, Satoshi Yokoshima, Tohru Fukuyama, Hiroyuki Honda, Ryuji Kato
JOURNAL OF BIOMOLECULAR SCREENING, 21, 795 (2016)
(doi: 10.1177/1087057116645500)


Total Synthesis of (−)-Daphenylline


Ryosuke Yamada, Yohei Adachi, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed, 55, 6067 (2016)
(doi: 10.1002/anie.201601958)
This paper was selected as a VIP.

Total Synthesis of Lycopalhine A


Yuji Ochi, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 18, 1494 (2016)
(doi: 10.1021/acs.orglett.6b00338)


2015


Synthetic Studies on Huperzine R: Construction of the 1-Azabicyclo[5.4.3]tetradec-6-ene Core


Hiroshi Kumazaki, Rie Nakajima, Yuka Bessho, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 26, 2131 (2015)
(doi: 10.1055/s-0034-1380425)

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes


Kyosuke Ueda, Hirotatsu Umihara, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 17, 3191 (2015)
(doi: 10.1021/acs.orglett.5b01351)

Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight-Membered Cyclic Nitrone to Construct the 2-Azabicyclo[3.3.1]nonane Framework


Takuya Higo, Tomoya Ukegawa, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 54, 7367 (2015)
(doi: 10.1002/anie.201501633)

Synthetic Studies on Plakinidines


Takashi Komori, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 26, 1537 (2015)
(doi: 10.1055/s-0034-1380689)


2014


Synthesis of (−)-Oxycodone


Atsushi Kimishima, Hirotatsu Umihara, Akihiro Mizoguchi, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 16, 6244 (2014)
(doi: 10.1021/ol503175n)

Asymmetric synthesis of 2-arylpiperazines


Satoshi Yokoshima, Kazutoshi Watanabe, Fumiaki Uehara, Yoshihiro Usui, Hiroshi Tanaka
Bioorg. Med. Chem. Lett., 24, 5749 (2014)
(doi: 10.1016/j.bmcl.2014.10.047)

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
Proc. Natl. Acad. Sci. USA, 111, 10544 (2014)
(doi: 10.1073/pnas.1402171111)

A Unified Strategy for Kainoid Synthesis


Masaya Fujii, Satoshi Yokoshima, Tohru Fukuyama
Eur. J. Org. Chem., 2014, 4823 (2014)
(doi: 10.1002/ejoc.201402452)

Total Synthesis of (−)-Lepistine


Yusuke Kitabayashi, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 16, 2862 (2014)
(doi: 10.1021/ol5010033)
This paper was featured on Synfacts.

New photocleavable linker: α-Thioacetophenone-type linker


Hirotaka Yonezawa, Yoshitake Nishiyama, Koji Takeo, Takeshi Iwatsubo, Taisuke Tomita, Satoshi Yokoshima, Tohru Fukuyama
Bioorg. Med. Chem. Lett., 24, 2831 (2014)
(doi: 10.1016/j.bmcl.2014.04.104)

Total Synthesis of (−)-Lepenine


Yoshitake Nishiyama, Yuki Han-ya, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 136, 6598 (2014)
(doi: 10.1021/ja503023h)
This paper was featured on Synfacts.

Binding of longer A beta to transmembrane domain 1 of presenilin 1 impacts on A beta 42 generation

Yu Ohki, Naoaki Shimada, Aya Tominaga, Satoko Osawa, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
Molecular Neurodegeneration, 9, 7 (2014)
(doi: 10.1186/1750-1326-9-7)


2013


Total Synthesis of Ecteinascidin 743


Fumiki Kawagishi, Tatsuya Toma, Tomohiko Inui, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 135, 13684 (2013)
(doi: 10.1021/ja408034x)
This paper was featured on Synfacts.

Total Synthesis of Lysergic Acid



Satoshi Umezaki, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 15, 4230 (2013)
(doi: 10.1021/ol4019562)

Effect of Helical Conformation and Side Chain Structure on gamma-Secretase Inhibition by beta-Peptide Foldamers: Insight into Substrate Recognition

Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
J. Med. Chem., 56, 1443 (2013)
(doi: 10.1021/jm301306c)

Total Syntheses of Lyconadins A-C


Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 135, 3243 (2013)
(doi: 10.1021/ja312065m)

2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide


Masaya Fujii, Takuya Nishimura, Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 15, 232 (2013)
(doi: 10.1021/ol303320c)
This paper was featured on Synfacts and ChemInform.


2012


Activity-Dependent Proteolytic Cleavage of Neuroligin-1

Kunimichi Suzuki, Yukari Hayashi, Soichiro Nakahara, Hiroshi Kumazaki, Johannes Prox, Keisuke Horiuchi, Mingshuo Zeng, Shun Tanimura, Yoshitake Nishiyama, Satoko Osawa, Atsuko Sehara-Fujisawa, Paul Saftig, Satoshi Yokoshima, Tohru Fukuyama, Norio Matsuki, Ryuta Koyama, Taisuke Tomita, Takeshi Iwatsubo
Neuron, 76, 410 (2012)
(doi: 10.1016/j.neuron.2012.10.003)

Total Synthesis of (−)-Lycoposerramine-S


Naoaki Shimada, Yuzo Abe, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 11824 (2012)
(doi: 10.1002/anie.201206863)
This paper was featured on Synfacts.

Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton


Kotaro Iwasaki, Rentaro Kanno, Toshiharu Morimoto, Tohru Yamashita, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 9160 (2012)
(doi: 10.1002/anie.201204726)

Total Synthesis of (−)-Lemonomycin


Atsushi Yoshida, Michinori Akaiwa, Tomohiro Asakawa, Yoshitaka Hamashima, Satoshi Yokoshima, Tohru Fukuyama, Toshiyuki Kan Chem. Eur. J., 18, 11192 (2012)
(doi: 10.1002/chem.201202073q)

Total Synthesis of (−)-Isoschizogamine


Yusuke Miura, Noriyuki Hayashi, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 134, 11995 (2012)
(doi: 10.1021/ja305856q)
This paper was featured on Synfacts.

Synthetic Studies toward Ecteinascidin 743 (Trabectedin)


Takahiro Imai, Hiyoku Nakata, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 44, 2743 (2012)
(doi: 10.1055/s-0032-1316579)

Total Synthesis of Gelsemoxonine


Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima, Tohru Fukuyama
Pure Appl. Chem., 84, 1643 (2012)
(doi: 10.1351/PAC-CON-11-10-25)

A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine


Tomoaki Maehara, Rentaro Kanno, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 14, 1946 (2012)
(doi: 10.1021/ol3005613)

Total Synthesis of (−)-Anisatin


Akihiro Ogura, Kohei Yamada, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 14, 1632 (2012)
(doi: 10.1021/ol300390k)
This paper was featured on Synfacts.

Identification of novel deoxyribofuranosyl indole antimicrobial agents

Atmika Paudel, Hiroshi Hamamoto, Yoshihisa Kobayashi, Satoshi Yokoshima, Tohru Fukuyama, Kazuhisa Sekimizu
The Jornal of Antibiotics, 65, 53 (2012)
(doi: 10.1038/ja.2011.110)


2011


A Practical Synthesis of (−)-Kainic Acid


Satoshi Takita, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 3848 (2011)
(doi: 10.1055/s-0031-1289570)

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1


Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
EMBO Journal, 30, 4815 (2011)
(doi: 10.1038/emboj.2011.372)

Total Synthesis of Gelsemoxonine


Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 133, 17634 (2011)
(doi: 10.1021/ja109516f)
This paper was featured on "Chem Station" (only Japanese version available).

Total Synthesis of (−)-Histrionicotoxin


Yohei Adachi, Noriyuki Kamei, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 13, 4446 (2011)
(doi: 10.1021/ol2018032)

Copper-Mediated Aryl Amination: In Situ Generation of an Active Copper(I) Species

Takashi Komori, Nobuhiro Satoh, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 1859 (2011)
(doi: 10.1055/s-0030-1260954)

Total Synthesis of (−)-Salinosporamide A


Nobuhiro Satoh, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 13, 3028 (2011)
(doi: 10.1021/ol200886j)

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

Nobumasa Takasugi, Tomoki Sasaki, Kunimichi Suzuki, Satoko Osawa, Hayato Isshiki, Yukiko Hori, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Virginia M.-Y. Lee, John Q. Trojanowski, Taisuke Tomita, Takeshi Iwatsubo
J. Neurosci., 31, 6850 (2011)
(doi: 10.1523/JNEUROSCI.6467-10.2011)

A Practical Synthesis of (−)-Kainic Acid


Satoshi Takita, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 13, 2068 (2011)
(doi: 10.1021/ol200434a)

Concise Total Synthesis of (+)-Lyconadin A


Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 133, 418 (2011)
(doi: 10.1021/ja109516f)


2010


Total Synthesis of (−)-Morphine


Hifumi Koizumi, Satoshi Yokoshima, Tohru Fukuyama
Chem. Asian. J., 5, 2192 (2010)
(doi: 10.1002/asia.201000458)

Total synthesis of (+)-vinblastine: Control of the stereochemistry at C18


Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
The Chemical Record, 10, 101 (2010)
(doi: 10.1002/tcr.200900025)

Total Synthesis of (−)-Mersicarpine


Rie Nakajima, Tsuyoshi Ogino, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 132, 1236 (2010)
(doi: 10.1021/ja9103233)


2009


Synthetic Studies toward (+)-Lysergic Acid: Construction of the Tetracyclic Ergoline Skeleton


Tohru Inoue, Satoshi Yokoshima, Tohru Fukuyama
Heterocycles, 79, 373 (2009)
(doi: 10.3987/COM-08-S(D)42)

Total Synthesis of (±)-Morphine


Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama
Heterocycles, 77, 1219 (2009)
(doi: 10.3987/COM-08-S(F)103)

A Practical Synthesis of (−)-Oseltamivir


Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama
Tetrahedron, 64, 3239 (2009)
(doi: 10.1016/j.tet.2008.09.103)

Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker


Satoshi Yokoshima, Yuzo Abe, Naoto Watanabe, Yoichi Kita, Takeshi Iwatsubo, Taisuke Tomita, Tohru Fukuyama
Bioorg. Med. Chem. Lett., 19, 6869 (2009)
(doi: 10.1016/j.bmcl.2009.10.086)

Total Synthesis of (−)-Huperzine A


Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 11, 5354 (2009)
(doi: 10.1021/ol9022408)

Method for Producing Morphine


Tohru Fukuyama, Satoshi Yokoshima, Hifumi Koizumi
PCT Int. Appl., WO 2009154041 (2009)
[link]


2008


Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit


Hiroaki Yamagishi, Koji Matsumoto, Kotaro Iwasaki, Tohru Miyazaki, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
Org. Lett., 10, 2369 (2008)
(doi: 10.1021/ol800527p)

(1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids


Takuya Nishimura, Kouhei Yamada, Tohru Takebe, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 10, 2601 (2008)
(doi: 10.1021/ol8008655)

A Simple Chiral Template for the Synthesis of Fuctionalized α-Arylglycine Derivatives


Hiyoku Nakata, Takahiro Imai, Satoshi Yokoshima, Tohru Fukuyama
Heterocycles, 76, 747 (2008)
(doi: 10.3987/COM-08-S(N)87)

Oseltamivir Enhances Hippocampal Network Synchronization

Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya
J. Pharmacol. Sci., 106, 659 (2008)
(doi: 10.1254/jphs.SC0070467)

Isoquinuclidine derivative and method for producing 1-cyclohexene-1-carboxylic acid derivative by using the same

Tohru Fukuyama, Satoshi Yokoshima, Nobuhiro Satoh
PCT Int. Appl., WO 2008013269 (2008)
[link]


2007


Synthesis of (+)-Vinblastine and Its Analogues


Tohru Miyazaki, Satoshi Yokoshima, Siro Simizu, Hiroyuki Osada, Hidetoshi Tokuyama, Tohru Fukuyama
Org. Lett., 9, 4737 (2007)
(doi: 10.1021/ol702040y)

A Practical Synthesis of (−)-Oseltamivir


Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 46, 5734 (2007)
(doi: 10.1002/anie.200701754)


2006


Total Synthesis of (±)-Morphine


Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama
Org. Lett., 8, 5311 (2006)
(doi: 10.1021/ol062112m)

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari
Bioorg. Med. Chem. Lett., 16, 4184 (2006)
(doi: 10.1016/j.bmcl.2006.05.091)

Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima, Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari, Tohru Fukuyama
Bioorg. Med. Chem. Lett., 16, 3813 (2006)
(doi: 10.1016/j.bmcl.2006.04.025)


2004


Stereocontrolled Total Synthesis of (+)-Vincristine


Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
Proc. Natl. Acad. Sci. USA, 101, 11966 (2004)
(doi: 10.1073/pnas.0401323101)


2003


A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes


Hidetoshi Tokuyama, Tohru Miyazaki, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 1512 (2003)
(doi: 10.1055/s-2003-40861)

Stereocontrolled Total Synthesis of (+)-Vinblastine


Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, Tohru Fukuyama
Pure Appl. Chem., 75, 29 (2003)
(doi: 10.1351/pac200375010029)


2002


Reduction of Ethanethiol Esters to Aldehydes


Hidetoshi Tokuyama, Satoshi Yokoshima, Shao-Cheng Lin, Leping Li, Tohru Fukuyama
Synthesis, 1121 (2002)
(doi: 10.1055/s-2002-31969)

Stereocontrolled Total Synthesis of (+)-Vinblastine


Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, Tohru Fukuyama
J. Am. Chem. Soc., 124, 2137 (2002)
(doi: 10.1021/ja0177049)

A Novel Conversion of α-Aminonitrile to Amide


Satoshi Yokoshima, Tetsuji Kubo, Hidetoshi Tokuyama, Tohru Fukuyama
Chem. Lett., 122 (2002)
(doi: 10.1246/cl.2002.122)


2001


Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. Mirabilis

Kaoru Warabi, Yoichi Nakao, Shigeki Matsunaga, Tohru Fukuyama, Toshiyuki Kan, Satoshi Yokoshima, Nobuhiro Fusetani
Comparative Biochemistry and Physiology Part B, 128, 27 (2001)
(doi: 10.1016/S1096-4959(00)00316-X)


2000


Enantioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration


Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
Angew. Chem. Int. Ed., 39, 4073 (2000)
(doi: 10.1002/1521-3773(20001117)39:22<4073::AID-ANIE4073>3.0.CO;2-V)


1998


Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones


Hidetoshi Tokuyama, Satoshi Yokoshima, Tohru Yamashita, Shao-Cheng Lin, Leping Li, Tohru Fukuyama
J. Braz. Chem. Soc., 9, 381 (1998)
(doi: 10.1590/S0103-50531998000400011)

A Novel Ketone Synthesis by a Palladium-Catalyzed Reaction of Thiol Esters and Organozinc Reagents


Hidetoshi Tokuyama, Satoshi Yokoshima, Tohru Yamashita, Tohru Fukuyama
Tetrahedron Lett., 39, 3189 (1998)
(doi: 10.1016/S0040-4039(98)00456-0)


福山透 前特任教授（前分野長）の論文リストはこちらをご覧ください。