論文リスト


2019 2018 2017 2016 2015 2014 2013 2012 2011
2010 2009 2008 2007 2006 2005 2004 2003 2002 2001
2000 1999 1998 1997 1996 1995 1994 1993 1992 1990
1980s

Corrections


2019


Synthesis of Majusculamides A and B



Daisuke Nakajima, Kosuke Sueyoshi, Kensuke Orihara, Toshiaki Teruya, Satoshi Yokoshima
Synlett, 30, 924 (2019)
(doi: 10.1055/s-0037-1611805)


Synthetic Studies of Isoschizogamine: Alternative Preparation of the Key Intermediate


Noriyuki Hayashi, Yusuke Miura, Satoshi Yokoshima, Tohru Fukuyama
Chem. Pharm. Bull., 67, 64 (2019)
(doi: 10.1248/cpb.c18-00718)



2018


Total Synthesis of Lycoposerramine-R


Shinya Watanabe, Masatsugu Ishikawa, Toshimune Nomura, Tohru Fukuyama, Satoshi Yokoshima
Synlett, 29, 2377 (2018)
(doi: 10.1055/s-0037-1611024)


A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model


Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa & Hidenori Ichijo
Nat. Commun., 9, 2668 (2018)
(doi: 10.1038/s41467-018-05127-2)


Synthetic Studies of the Daphniphyllum Alkaloids: A Cooperative Reaction of Proximal Functional Groups Forming a Tetracyclic System


Ryosuke Yamada, Tohru Fukuyama, Satoshi Yokoshima
Org. Lett., 20, 4504 (2018)
(doi: 10.1021/acs.orglett.8b01800)


Synthesis of the [7-5-5] Tricyclic Core of Daphniphyllum Alkaloids


Yusuke Kitabayashi, Tohru Fukuyama, Satoshi Yokoshima
Org. Biomol. Chem., 16, 3556 (2018)
(doi: 10.1039/C8OB00859K)


Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring


Kensuke Orihara, Fumiki Kawagishi, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 29, 769 (2018)
(doi: 10.1055/s-0037-1609150)


Total Synthesis of Huperzine R


Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 20, 119 (2018)
(doi: 10.1021/acs.orglett.7b03555)



2017


Synthesis of Cardiopetaline via a Wagner–Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group


Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 19, 5833 (2017)
(doi: 10.1021/acs.orglett.7b02812)


Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

Yoshihiro Usui, Fumiaki Uehara, Shinsuke Hiki, Kazutoshi Watanabe, Hiroshi Tanaka, Aya Shouda, Satoshi Yokoshima, Keiichi Aritomo, Takashi Adachi, Kenji Fukunaga, Shinji Sunada, Mika Nabeno, Ken-Ichi Saito, Jun-ichi Eguchi, Keiji Yamagami, Shouichi Asano, Shinji Tanaka, Satoshi Yuki, Narihiko Yoshii, Masatake Fujimura, Takashi Horikawa
Bioorganic & Medicinal Chemistry Letters, 27, 3726 (2017)
(doi: 10.1016/j.bmcl.2017.06.078)


Total Synthesis of (+)-lysergic acid


Rentaro Kanno, Satoshi Yokoshima, Motomu Kanai, Tohru Fukuyama
The Jornal of Antibiotics, 71, 240 (2018)
(doi: 10.1038/ja.2017.80)


Total Synthesis of Huperzine Q


Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 19, 3684 (2017)
(doi: 10.1021/acs.orglett.7b01633)


High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano
Scientific Reports, 7, 4029 (2017)
(doi: 10.1038/s41598-017-03567-2)


Total Syntheses of Aurachins A and B


Haruhiko Hattori, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 56, 6980 (2017)
(doi: 10.1002/anie.201702204)


Total Synthesis of (−)-Morphine


Hirotatsu Umihara, Satoshi Yokoshima, Masayuki Inoue, Tohru Fukuyama
Chem. Eur. J., 23, 6993 (2017)
(doi: 10.1002/chem.201701438)


Total Synthesis of (−)-Tetrodotoxin and 11-norTTX-6(R)-ol


Tomoaki Maehara, Keisuke Motoyama, Tatsuya Toma, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 56, 1549 (2017)
(doi: 10.1002/anie.201611574)
This paper was selected as a Hot Paper.


2016


Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation


Ota, Yu; Chinen, Takumi; Yoshida, Keisuke; Kudo, Shun; Nagumo, Yoko; Shiwa, Yuh; Yamada, Ryosuke; Umihara, Hirotatsu; Iwasaki, Kotaro; Masumoto, Hiroshi; Yokoshima, Satoshi; Yoshikawa, Hirofumi; Fukuyama, Tohru; Kobayashi, Junichi; Usui, Takeo
ChemBioChem, 17, 1616 (2016)
(doi: 10.1002/cbic.201600075/abstract)


Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B


Kawai, Shun; Sasaki, Hiroto; Okada, Norihiro; Kanie, Kei; Yokoshima, Satoshi;Fukuyama, Tohru;Honda, Hiroyuki; Kato, Ryuji
JOURNAL OF BIOMOLECULAR SCREENING, 21, 795 (2016)
(doi: 10.1177/1087057116645500)


BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

Miyagawa, Toji; Ebinuma, Ihori; Morohashi, Yuichi; Hori, Yukiko; Chang, Mee Young; Hattori, Haruhiko; Maehara, Tomoaki; Yokoshima, Satoshi; Fukuyama, Tohru; Tsuji, Shoji; Iwatsubo, Takeshi; Prendergast, George C.; Tomita, Taisuke
HUMAN MOLECULAR GENETICS, 25, 2948 (2016)
(doi: 10.1093/hmg/ddw146)


Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules


Satoshi Yokoshima, Masatsugu Ishikawa, Youko Beniyama, Tohru Fukuyama
Chem. Phaem. Bull, 64, 1528 (2016)
(doi: 10/64_c16-00507)


Total Synthesis of Lycopalhine A


Yuji Ochi, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 48, A (2016)
(doi: 10.1055/s-0036-1588878)


Unified Total Synthesis of Five Gelsedine-Type Alkaloids: (−)-Gelsenicine, (−)-Gelsedine, (−)-Gelsedilam, (−)-14-Hydroxygelsenicine, and (−)-14,15-Dihydroxygelsenicine


Takaaki Harada, Jun Shimokawa, Tohru Fukuyama
Org. Lett., 18, 4622 (2016)
(doi: 10.1021/acs.orglett.6b02263)


Antiproliferative Activity of Amathaspiramide Alkaloids and Analogs

Jun Shimokawa, Koji Chiyoda, Hirotatsu Umihara, Tohru Fukuyama
Chem. Pharm. Bull., 64, 1239 (2016)
(doi: 10.1248/cpb.c16-00256)


Conversion of Vindoline into 11-Mesyloxytabersonine


Yuki Han-ya, Tomohiko Inui, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
Chem. Pharm. Bull., 64, 800 (2016)
(doi: 10.1248/cpb.c16-00175)


Total Synthesis of (−)-Cardiopetaline


Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 18, 2359 (2016)
(doi: 10.1021/acs.orglett.6b00789)


Development of a Divergent Synthetic Route to the Erythrina Alkaloids: Asymmetric Syntheses of 8-Oxo-erythrinine, Crystamidine, 8-Oxo-erythraline, and Erythraline


Hirotatsu Umihara, Tomomi Yoshino, Jun Shimokawa, Masato Kitamura, Tohru Fukuyama
Angew. Chem. Int. Ed, 55, 6915 (2016)
(doi: 10.1002/anie.201602650)


Total Synthesis of (−)-Daphenylline


Ryosuke Yamada, Yohei Adachi, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed, 55, 6067 (2016)
(doi: 10.1002/anie.201601958)
This paper was selected as a VIP.

Total Synthesis of Lycopalhine A


Yuji Ochi, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 18, 1494 (2016)
(doi: 10.1021/acs.orglett.6b00338)


2015


Synthesis of the Common Core Structure of the Stemofoline Alkaloids


Eiji Ideue, Jun Shimokawa and Tohru Fukuyama
Org. Lett., 17, 4964 (2015)
(doi: 10.1021/acs.orglett.5b02373)

Synthetic Studies on Huperzine R: Construction of the 1-Azabicyclo[5.4.3]tetradec-6-ene Core


Hiroshi Kumazaki, Rie Nakajima, Yuka Bessho, Satoshi Yokoshima and Tohru Fukuyama
Synlett, 26, 2131 (2015)
(doi: 10.1055/s-0034-1380425)

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes

Kyosuke Ueda, Hirotatsu Umihara, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 17, 3191 (2015)
(doi: 10.1021/acs.orglett.5b01351)

Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight-Membered Cyclic Nitrone to Construct the 2-Azabicyclo[3.3.1]nonane Framework


Takuya Higo, Tomoya Ukegawa, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed., 54, 7367 (2015)
(doi: 10.1002/anie.201501633)

Synthetic Studies on Plakinidines

Takashi Komori, Satoshi Yokoshima and Tohru Fukuyama
Synlett, 26, 1537 (2015)
(doi: 10.1055/s-0034-1380689)


2014


Synthesis of (−)-Oxycodone


Atsushi Kimishima, Hirotatsu Umihara, Akihiro Mizoguchi, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 6244 (2014)
(doi: 10.1021/ol503175n)

Asymmetric synthesis of 2-arylpiperazines

Satoshi Yokoshima, Kazutoshi Watanabe, Fumiaki Uehara, Yoshihiro Usui and Hiroshi Tanaka
Bioorg. Med. Chem. Lett., 24, 5749 (2014)
(doi: 10.1016/j.bmcl.2014.10.047)

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
Proc. Natl. Acad. Sci. USA, 111, 10544 (2014)
(doi: 10.1073/pnas.1402171111)

A Unified Strategy for Kainoid Synthesis


Masaya Fujii, Satoshi Yokoshima and Tohru Fukuyama
Eur. J. Org. Chem., 2014, 4823 (2014)
(doi: 10.1002/ejoc.201402452)

Total Synthesis of (−)-Lepistine


Yusuke Kitabayashi, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 2862 (2014)
(doi: 10.1021/ol5010033)
This paper was featured on Synfacts.

New photocleavable linker: α-Thioacetophenone-type linker

Hirotaka Yonezawa, Yoshitake Nishiyama, Koji Takeo, Takeshi Iwatsubo, Taisuke Tomita, Satoshi Yokoshima and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 24, 2831 (2014)
(doi: 10.1016/j.bmcl.2014.04.104)

Total Synthesis of (−)-Lepenine


Yoshitake Nishiyama, Yuki Han-ya, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 136, 6598 (2014)
(doi: 10.1021/ja503023h)
This paper was featured on Synfacts.

Development of a Route to Chiral Epidithiodioxopiperazine Moieties and Application to the Asymmetric Synthesis of (+)-Hyalodendrin


Ren Takeuchi, Jun Shimokawa and Tohru Fukuyama
Chem. Sci., 5, 2003 (2014)
(doi: 10.1039/C3SC53222D)

TMSCN/DBU-Mediated Facile Redox Transformation of α,β-Unsaturated Aldehydes to Carboxylic Acid Derivatives

Hiromi Kaise, Jun Shimokawa and Tohru Fukuyama
Org. Lett., 16, 727 (2014)
(doi: 10.1021/ol403415z)

Stereoselective Synthesis of Spirotryprostatin A


Katsushi Kitahara, Jun Shimokawa and Tohru Fukuyama
Chem. Sci., 5, 904 (2014)
(doi: 10.1039/C3SC52525B)


2013


Total Synthesis of Ecteinascidin 743


Fumiki Kawagishi, Tatsuya Toma, Tomohiko Inui, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 135, 13684 (2013)
(doi: 10.1021/ja408034x)
This paper was featured on Synfacts.

Total Synthesis of Lysergic Acid


Satoshi Umezaki, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 15, 4230 (2013)
(doi: 10.1021/ol4019562)

Total Syntheses of Lyconadins A-C


Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 135, 3243 (2013)
(doi: 10.1021/ja312065m)

2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide

Masaya Fujii, Takuya Nishimura, Takahiro Koshiba, Satoshi Yokoshimaa and Tohru Fukuyama
Org. Lett., 15, 232 (2013)
(doi: 10.1021/ol303320c)
This paper was featured on Synfacts and ChemInform.

Modified McFadyen-Stevens Reaction for a Versatile Synthesis of Aliphatic/Aromatic Aldehydes: Design, Optimization, and Mechanistic Investigations

Yuri Iwai, Takashi Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa and Tohru Fukuyama
Chem. Sci., 4, 1111 (2013)
(doi: 10.1039/C2SC22045H)


2012


Activity-Dependent Proteolytic Cleavage of Neuroligin-1

Kunimichi Suzuki, Yukari Hayashi, Soichiro Nakahara, Hiroshi Kumazaki, Johannes Prox, Keisuke Horiuchi, Mingshuo Zeng, Shun Tanimura, Yoshitake Nishiyama, Satoko Osawa, Atsuko Sehara-Fujisawa, Paul Saftig, Satoshi Yokoshima, Tohru Fukuyama, Norio Matsuki, Ryuta Koyama, Taisuke Tomita and Takeshi Iwatsubo
Neuron, 76, 410 (2012)
(doi: 10.1016/j.neuron.2012.10.003)

Total Synthesis of (−)-Lycoposerramine-S


Naoaki Shimada, Yuzo Abe, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 11824 (2012)
(doi: 10.1002/anie.201206863)
This paper was featured on Synfacts.

Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton


Kotaro Iwasaki, Rentaro Kanno, Toshiharu Morimoto, Tohru Yamashita, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 9160 (2012)
(doi: 10.1002/anie.201204726)

Total Synthesis of (−)-Lemonomycin


Atsushi Yoshida, Michinori Akaiwa, Tomohiro Asakawa, Yoshitaka Hamashima, Satoshi Yokoshima, Tohru Fukuyama, Toshiyuki Kan Chem. Eur. J., 18, 11192 (2012)
(doi: 10.1002/chem.201202073q)

Total Synthesis of (−)-Isoschizogamine


Yusuke Miura, Noriyuki Hayashi, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 134, 11995 (2012)
(doi: 10.1021/ja305856q)
This paper was featured on Synfacts.

Synthetic Studies toward Ecteinascidin 743 (Trabectedin)


Takahiro Imai, Hiyoku Nakata, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 44, 2743 (2012)
(doi: 10.1055/s-0032-1316579)

Convenient Synthesis of α-Diazoacetates from α-Bromoacetates and N,N'-Ditosylhydrazine: Preparation of Benzyl Diazoacetate

Eiji Ideue, Tatsuya Toma, Jun Shimokawa, Tohru Fukuyama
Org. Synth., 89, 501 (2012)
[link]

Efficient Synthesis of Oxime Using O-TBS-N-Tosylhydroxylamine: Preparation of (2Z)-4-(Benzyloxy)but-2-enal Oxime

Katsushi Kitahara, Tatsuya Toma, Jun Shimokawa, Tohru Fukuyama
Org. Synth., 89, 480 (2012)
[link]

Total Synthesis of Gelsemoxonine


Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima, and Tohru Fukuyama
Pure Appl. Chem., 84, 1643 (2012)
(doi: 10.1351/PAC-CON-11-10-25)

A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine

Tomoaki Maehara, Rentaro Kanno, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 14, 1946 (2012)
(doi: 10.1021/ol3005613)

Total Synthesis of (−)-Anisatin


Akihiro Ogura, Kohei Yamada, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 14, 1632 (2012)
(doi: 10.1021/ol300390k)
This paper was featured on Synfacts.

Total Syntheses of All the Amathaspiramides


Koji Chiyoda, Jun Shimokawa, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 2505 (2012)
(doi: 10.1002/anie.201109221)
This paper was selected as a HotPaper.


2011


A Practical Synthesis of (−)-Kainic Acid


Satoshi Takita, Satoshi Yokoshima and Tohru Fukuyama
Synthesis, 3848 (2011)
(doi: 10.1055/s-0031-1289570)

Total Synthesis of Gelsemoxonine


Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 133, 17634 (2011)
(doi: 10.1021/ja109516f)
This paper was featured on "Chem Station" (only Japanese version available).

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1


Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
EMBO Journal, 30, 4815 (2011)
(doi: 10.1038/emboj.2011.372)

Total Synthesis of (−)-Histrionicotoxin


Yohei Adachi, Noriyuki Kamei, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 13, 4446 (2011)
(doi: 10.1021/ol2018032)

Copper-Mediated Aryl Amination: In Situ Generation of an Active Copper(I) Species

Takashi Komori, Nobuhiro Satoh, Satoshi Yokoshima and Tohru Fukuyama
Synlett, 1859 (2011)
(doi: 10.1055/s-0030-1260954)

Total Synthesis of Tryprostatins A and B


Takayuki Yamakawa, Eiji Ideue, Yuzo Iwaki, Ayumu Sato, Hidetoshi Tokuyama, Jun Shimokawa and Tohru Fukuyama
Tetrahedron, 67, 6547 (2011)
(doi: 10.1016/j.tet.2011.05.112)

Total Synthesis of (−)-Salinosporamide A


Nobuhiro Satoh, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 13, 3028 (2011)
(doi: 10.1021/ol200886j)

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

Nobumasa Takasugi, Tomoki Sasaki, Kunimichi Suzuki, Satoko Osawa, Hayato Isshiki, Yukiko Hori, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Virginia M.-Y. Lee, John Q. Trojanowski, Taisuke Tomita and Takeshi Iwatsubo
J. Neurosci., 31, 6850 (2011)
(doi: 10.1523/JNEUROSCI.6467-10.2011)

Total Synthesis of (−)-Conophylline and (−)-Conophyllidine


Yuki Han-ya, Hidetoshi Tokuyama and Tohru Fukuyama
Angew. Chem. Int. Ed., 50, 4884 (2011)
(doi: 10.1002/anie.201100981)

A Practical Synthesis of (−)-Kainic Acid


Satoshi Takita, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 13, 2068 (2011)
(doi: 10.1021/ol200434a)

Concise Total Synthesis of (+)-Lyconadin A


Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 133, 418 (2011)
(doi: 10.1021/ja109516f)


2010


Total Synthesis of Tryprostatins A and B


Takayuki Yamakawa, Eiji Ideue, Jun Shimokawa and Tohru Fukuyama
Angew. Chem. Int. Ed., 49, 9262 (2010)
(doi: 10.1002/anie.201004963)

Total Synthesis of (−)-Morphine


Hifumi Koizumi, Satoshi Yokoshima and Tohru Fukuyama
Chem. Asian. J., 5, 2192 (2010)
(doi: 10.1002/asia.201000458)

Synthesis of the optically active key intermediate of FR901483


Shigeru Ieda, Toshiyuki Kan and Tohru Fukuyama
Tetrahedron Lett., 51, 4027 (2010)
(doi: 10.1016/j.tetlet.2010.05.089)

Total Synthesis of (+)-Manzamine A


Tatsuya Toma, Yoichi Kita and Tohru Fukuyama
J. Am. Chem. Soc., 132, 10232 (2010)
(doi: 10.1021/ja103721s)

Total synthesis of (+)-vinblastine: Control of the stereochemistry at C18


Satoshi Yokoshima, Hidetoshi Tokuyama and Tohru Fukuyama
The Chemical Record, 10, 101 (2010)
(doi: 10.1002/tcr.200900025)

Total Synthesis of (−)-Mersicarpine


Rie Nakajima, Tsuyoshi Ogino, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 132, 1236 (2010)
(doi: 10.1021/ol9022408)


2009


Method for Producing Morphine


Tohru Fukuyama, Satoshi Yokoshima and Hifumi Koizumi
PCT Int. Appl., WO 2009154041 (2009)
[link]

Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

Satoshi Yokoshima, Yuzo Abe, Naoto Watanabe, Yoichi Kita, Takeshi Iwatsubo, Taisuke Tomita and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 19, 6869 (2009)
(doi: 10.1016/j.bmcl.2009.10.086)

Total Synthesis of (+)-Haplophytine


Hirofumi Ueda, Hitoshi Satoh, Koji Matsumoto, Kenji Sugimoto, Tohru Fukuyama and Hidetoshi Tokuyama
Angew. Chem. Int. Ed., 48, 7600 (2009)
(doi: 10.1002/anie.200902192)

Total Synthesis of (−)-Huperzine A


Takahiro Koshiba, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 11, 5354 (2009)
(doi: 10.1021/ol9022408)

Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy


Toshiki Kurokawa, Minetaka Isomura, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 775 (2009)
(doi: 10.1055/s-0028-1087948)

Stereocontrolled Total Synthesis of (±)-FR901483


Shigeru Ieda, Yusuke Asoh, Teppei Fujimoto, Haruka Kitaoka, Toshiyuki Kan and Tohru Fukuyama
Heterocycles, 79, 721 (2009)
(doi: 10.3987/COM-08-S(D)38)

Synthetic Studies toward (+)-Lysergic Acid: Construction of the Tetracyclic Ergoline Skeleton


Tohru Inoue, Satoshi Yokoshima and Tohru Fukuyama
Heterocycles, 79, 373 (2009)
(doi: 10.3987/COM-08-S(D)42)

A Practical Synthesis of (−)-Oseltamivir


Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima and Tohru Fukuyama
Tetrahedron, 64, 3239 (2009)
(doi: 10.1016/j.tet.2008.09.103)

Total Synthesis of (±)-Morphine


Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan and Tohru Fukuyama
Heterocycles, 77, 1219 (2009)
(doi: 10.3987/COM-08-S(F)103)

Palladium-catalyzed Coupling of N-Heteroaryl Sulfides with Organozinc Reagents

Takahiro Koshiba, Tohru Miyazaki, Hidetoshi Tokuyama and Tohru Fukuyama
Heterocycles, 77, 233 (2009)
(doi: 10.3987/COM-08-S(F)49)


2008


Total Synthesis of (−)-Serotobenine


Yasuaki Koizumi, Hideki Kobayashi, Toshiyuki Wakimoto, Takumi Furuta, Tohru Fukuyama and Toshiyuki Kan
J. Am. Chem. Soc., 130, 16854 (2008)
(doi: 10.1021/ja807676v)

Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene as a Non-Lewis-Basic Cation Scavenger

Kentaro Okano, Kei-ichiro Okuyama, Tohru Fukuyama and Hidetoshi Tokuyama
Synlett, 13, 1977 (2008)
(doi: 10.1055/s-2008-1077980)

Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework


Yoichi Kita, Tatsuya Toma, Toshiyuki Kan and Tohru Fukuyama
Org. Lett., 10, 3251 (2008)
(doi: 10.1021/ol801111r)

(1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids

Takuya Nishimura, Kouhei Yamada, Tohru Takebe, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 10, 2601 (2008)
(doi: 10.1021/ol8008655)

Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit


Hiroaki Yamagishi, Koji Matsumoto, Kotaro Iwasaki, Tohru Miyazaki, Satoshi Yokoshima, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 10, 2369 (2008)
(doi: 10.1021/ol800527p)

A Simple Chiral Template for the Synthesis of Fuctionalized α-Arylglycine Derivatives

Hiyoku Nakata, Takahiro Imai, Satoshi Yokoshima and Tohru Fukuyama
Heterocycles, 76, 747 (2008)
(doi: 10.3987/COM-08-S(N)88)

O-TBS-N-tosylhydroxylamine: A Reagent for Facile Conversion of Alcohols to Oximes

Katsushi Kitahara, Tatsuya Toma, Jun Shimokawa and Tohru Fukuyama
Org. Lett., 10, 2259 (2008)
(doi: 10.1021/ol800677p)

Total Synthesis of (−)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route


Hiroshi Sakaguchi, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 10, 1711 (2008)
(doi: 10.1021/ol800328q)

Oseltamivir Enhances Hippocampal Network Synchronization

Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki and Yuji Ikegaya
J. Pharmacol. Sci., 106, 659 (2008)
(doi: 10.1254/jphs.SC0070467)

Isoquinuclidine derivative and method for producing 1-cyclohexene-1-carboxylic acid derivative by using the same

Tohru Fukuyama, Satoshi Yokoshima and Nobuhiro Satoh
PCT Int. Appl., WO 2008013269 (2008)
[link]

Synthetic Studies on Altemicidin: Stereocontrolled Construction of the Core Framework

Toshiyuki Kan, Yuichiro Kawamoto, Tomohiro Asakawa, Takumi Furuta and Tohru Fukuyama
Org. Lett., 10, 169 (2008)
(doi: 10.1021/ol701940f)


2007


Synthetic Studies on Haplophytine: Protective Group Controlled Rearrangement


Koji Matsumoto, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 3137 (2007)
(doi: 10.1055/s-2007-990911)

Total Synthesis of (+)-Yatakemycin


Kentaro Okano, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Asian J., 3, 296 (2007)
(doi: 10.1002/asia.200700282)

A Versatile Synthesis of α-Amino Acid Derivatives via the Ugi Four-Component Condensation with a Novel Convertible Isonitrile

Kentaro Rikimaru, Arata Yanagisawa, Toshiyuki Kan and Tohru Fukuyama
Heterocycles, 73, 403 (2007)
(doi: 10.3987/COM-07-S(U)11)

Synthesis of (+)-Vinblastine and Its Analogues


Tohru Miyazaki, Satoshi Yokoshima, Siro Simizu, Hiroyuki Osada, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 9, 4737 (2007)
(doi: 10.1021/ol702040y)

Design and synthesis of thiazoline-thiazole hybrid macrocycles possessing strong binding affinity to Pb2+ and Cd2+

Fu She Han, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Commun., 3444 (2007)
(doi: 10.1039/b707904d)

Novel Structual Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity

Fu She Han, Hiroyuki Osajima, Mui Cheung, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Eur. J., 13, 3026 (2007)
(doi: 10.1002/chem.200601446)

N,N'-Ditosylhydrazine: A Convenient Reagent for Facile Synthesis of Diazoacetates

Tatsuya Toma, Jun Shimokawa and Tohru Fukuyama
Org. Lett., 9, 3195 (2007)
(doi: 10.1021/ol701432k)

A Practical Synthesis of (−)-Oseltamivir


Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed., 46, 5734 (2007)
(doi: 10.1002/anie.200701754)

Divergent Synthesis of Multifunctional Molecular Probes Enabled Elucidation of the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors on Presenilin-Type Aspartic Proteases

Haruhiko Fuwa, Yasuko Takahashi, Yu Konno, Naoto Watanabe, Hiroyuki Miyashita, Makoto Sasaki, Hideaki Natsugari, Toshiyuki Kan, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
ACS Chemical Biology, 2, 408 (2007)
(doi: 10.1021/cb700073y)

A Novel Indole Synthesis via Conjugate Addition of Pyrrolidine to o-Nitrophenylacetylenes

Hidetoshi Tokuyama, Takaki Makido, Yuki Han-ya and Tohru Fukuyama
Heterocycles, 72, 191 (2007)
(doi: 10.3987/COM-06-S(K)52)

Total Syntheses of FR900482


Hidetoshi Tokuyama, Masashi Suzuki and Tohru Fukuyama
J. Synth. Org. Chem. Jpn., 65, 470 (2007)

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

Toshiyuki Kan, Yoichi Kita, Yuichi Morohashi, Yusuke Tominari, Shinnosuke Hosoda, Taisuke Tomita, Hideaki Natsugari, Takeshi Iwatsubo and Tohru Fukuyama
Org. Lett., 9, 2055 (2007)
(doi: 10.1021/ol070376i)

Stereocontrolled Total Synthesis of (−)-Kainic Acid


Hiroshi Sakaguchi, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 9, 1635 (2007)
(doi: 10.1021/ol0631197)


2006


Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule

Fu She Han, Hiroyuki Osajima, Mui Cheung, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Commun., 1757 (2006)
(doi: 10.1039/b601628f)

Total Synthesis of (±)-Morphine


Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan and Tohru Fukuyama
Org. Lett., 8, 5311 (2006)
(doi: 10.1021/ol062112m)

Total Synthesis of (+)-Yatakemycin


Kentaro Okano, Hidetoshi Tokuyama and Tohru Fukuyama
J. Am. Chem. Soc., 128, 7136 (2006)
(doi: 10.1021/ja0619455)

Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima, Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari and Tohru Fukuyama

Bioorg. Med. Chem. Lett., 16, 3813 (2006)
(doi: 10.1016/j.bmcl.2006.04.025)

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita and Hideaki Natsugari
Bioorg. Med. Chem. Lett., 16, 4184 (2006)
(doi: 10.1016/j.bmcl.2006.05.091)

C-terminal Fragment of Presenilin is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)

Yuichi Morohashi, Toshiyuki Kan, Yusuke Tominari, Haruhiko Fuwa, Yumiko, Okamura, Naoto Watanabe, Chihiro Sato, Hideaki Natsugari, Tohru Fukuyama, Takeshi Iwatsubo and Taisuke Tomita
J. Biol. Chem., 281, 14670 (2006)
(doi: 10.1074/jbc.M513012200)

A Novel Synthesis of Bicyclo[3.3.0]octane Ring System via a Desymmetric C-H Insertion Reaction

Toshiyuki Kan, Tohru Inoue, Yuichiro Kawamoto, Mitsuhiro Yonehara and Tohru Fukuyama
Synlett, 1583 (2006)
(doi: 10.1055/s-2006-941603)


2005


Stereocontrolled Total Synthesis of (−)-Eudistomin C


Tohru Yamashita, Nobutaka Kawai, Hidetoshi Tokuyama and Tohru Fukuyama
J. Am. Chem. Soc., 127, 15038 (2005)
(doi: 10.1021/ja055832h)

Synthesis of Tetrahydro-β-carbolines via Radical Cyclization of 2-Alkenylthioanilides

Manami Iwadate, Tohru Yamashita, Hidetoshi Tokuyama and Tohru Fukuyama
Heterocycles, 66, 241 (2005)
(doi: )

Stereocontrolled Total Synthesis of (−)-Kainic Acid. Regio- and Stereoselective Lithiation of Pyrrolidine Ring with the (+)-Sparteine Surrogate


Yasuhiro Morita, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 7, 4337 (2005)
(doi: 10.1021/ol051408+)

Synthetic Studies on (−)-Lemonomycin: Stereocontrolled Construction of the 3,8-Diazabicyclo[3.2.1] Skeleton


Kentaro Rikimaru, Kazuki Mori, Toshiyuki Kan and Tohru Fukuyama
Chem. Commun., 394 (2005)
(doi: 10.1039/b415030a)

Synthesis of 2,3-Dialkylindoles from 2-Alkenylphenylisocyanides and Imines by Silyltelluride- and Tin Hydride-Mediated Sequential Radical Reactions

Masashi Kotani, Shigeru Yamago, Ayumu Satoh, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 1893 (2005)
(doi: 10.1055/s-2005-871931)


2004


Synthetic Studies on (+)-Naphthyridinomycin: Stereoselective Synthesis of the Tetracyclic Core Framework

Kazuki Mori, Kentaro Rikimaru, Toshiyuki Kan and Tohru Fukuyama
Org. Lett., 6, 3095 (2004)
(doi: 10.1021/ol048857e)

Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters

Tohru Fukuyama and Hidetoshi Tokuyama
Aldrichimica Acta, 37, 87 (2004)
[link]

Total Synthesis of (−)-Strychnine


Yosuke Kaburagi, Hidetoshi Tokuyama and Tohru Fukuyama
J. Am. Chem. Soc., 126, 10246 (2004)
(doi: 10.1021/ja046407b)

Stereocontrolled Total Synthesis of Potent Immunosuppressant FR901483

Toshiyuki Kan, Teppei Fujimoto, Yusuke Asoh, Shigeru Ieda, Haruka Kitaoka and Tohru Fukuyama
Org. Lett., 6, 2729 (2004)
(doi: 10.1021/ol049074w)

Total Synthesis of (−)-Ephedradine A (Orantine): An Efficient Construction of Optically Active Dihydrobenzofuran-ring via C-H Insertion Reaction


Wataru Kurosawa, Hideki Kobayashi, Toshiyuki Kan and Tohru Fukuyama
Tetrahedron, 60, 9615 (2004)
(doi: 10.1016/j.tet.2004.06.144)

Stereocontrolled Total Synthesis of (+)-Vincristine


Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama and Tohru Fukuyama
Proc. Natl. Acad. Sci. USA, 101, 11966 (2004)
(doi: 10.1073/pnas.0401323101)

Enantioselective Total Synthesis of FR900482


Masashi Suzuki, Mika Kambe, Hidetoshi Tokuyama and Tohru Fukuyama
J. Org. Chem., 69, 2831 (2004)
(doi: 10.1021/jo049862z)

4-(t-Butyldimethylsilyloxy)benzylidene Acetal: A Novel Benzylidene-type Protecting Group for 1,2-Diols

Yosuke Kaburagi, Hiroyuki Osajima, Kousei Shimada, Hidetoshi Tokuyama and Tohru Fukuyama
Tetrahedron Lett., 45, 3817 (2004)
(doi: 10.1016/j.tetlet.2004.03.065)

Stereoselective Nucleophilic Addition Reaction with a New Chiral Template and Its Application to Synthesis of Optically Active α-Aryglycine Derivatives

Shigemitsu Tohma, Kentaro Rikimaru, Atsushi Endo, Toshiyuki Kan and Tohru Fukuyama
Synthesis, 909 (2004)
(doi: 10.1055/s-2004-815980)

New Odorless Protocols for the Synthesis of Aldehydes and Ketones from Thiol Esters

Tohru Miyazaki, Yuki Han-ya, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 477 (2004)
(doi: 10.1055/s-2004-815427)

Highly Efficient Synthesis of Medium-Sized Lactams via Intramolecular Staudinger-Aza-Wittig Reaction of ω-Azide Pentaphenyl Ester: Synthesis and Biological Evaluation of LY411575 Analogues

Haruhiko Fuwa, Yumiko Okamura, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo, Toshiyuki Kan, Tohru Fukuyama and Hideaki Natsugari
Tetrahedron Lett., 45, 2323 (2004)
(doi: 10.1016/j.tetlet.2004.01.087)

Parallel Synthesis of DAPT Derivatives and Their γ-Secretase-Inhibitory Activity

Toshiyuki Kan, YusukeTominari, Kentaro Rikimaru, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 14, 1983 (2004)
(doi: 10.1016/j.bmcl.2004.01.067)

Ns Strategies: A Highly Versatile Synthetic Method for Amines

Toshiyuki Kan and Tohru Fukuyama
Chem. Commun., 353 (2004)
(doi: 10.1039/B311203A)

A Versatile Synthesis of α-Amino Acid Derivatives Via the Ugi Four-Component Condensation with a Novel Convertible Isonitrile

Kentaro Rikimaru, Arata Yanagisawa, Toshiyuki Kan and Tohru Fukuyama
Synlett, 41 (2004)
(doi: 10.1055/s-2003-43355)


2003


Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination

Kentaro Okano, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 5, 4987 (2003)
(doi: 10.1021/ol035942y)

Solid-Phase Synthesis of Photoaffinity Probes: Highly Efficient Incorporation of Biotin-tag and Cross-linking group

Toshiyuki Kan, Yusuke Tominari, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo and Tohru Fukuyama
Chem. Commun., 2244 (2003)
(doi: 10.1039/B306970B)

Stereocontrolled Total Synthesis of (−)-Aspidophytine


Shinjiro Sumi, Koji Matsumoto, Hidetoshi Tokuyama and Tohru Fukuyama
Tetrahedron, 59, 8571 (2003)
(doi: 10.1016/j.tet.2003.09.005)

Stereocontrolled Total Synthesis of (−)-Ephedradine A (Orantine)


Wataru Kurosawa, Toshiyuki Kan and Tohru Fukuyama
J. Am. Chem. Soc., 125, 8112 (2003)
(doi: 10.1021/ja036011k)

A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes

Hidetoshi Tokuyama, Tohru Miyazaki, Satoshi Yokoshima and Tohru Fukuyama
Synlett, 1512 (2003)
(doi: 10.1055/s-2003-40861)

A New Synthetic Route to Phomoidride B and Its Derivatives

Yuki Hayashi, Tetsuji Itoh and Tohru Fukuyama
Org. Lett., 5, 2235 (2003)
(doi: 10.1021/ol034471c)

An Efficient Synthesis of Optically Active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic Acid Esters via C-H Insertion Reaction

Wataru Kurosawa, Toshiyuki Kan and Tohru Fukuyama
Synlett, 1028 (2003)
(doi: 10.1055/s-2003-39316)

Sulindac Sulfide Is a Noncompetitive &gamma-Secretase Inhibitor That Preferentially Reduces Aβ 42 Generation

Yasuko Takahashi, Ikuo Hayashi, YusukeTominari, Kentaro Rikimaru, Yuichi Morohashi, Toshiyuki Kan, Hideaki Natsugari, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
J. Biol. Chem., 278, 18664 (2003)
[link]

Total Synthesis of Duocarmycins


Ken Yamada, Toshiki Kurokawa, Hidetoshi Tokuyama and Tohru Fukuyama
J. Am. Chem. Soc., 125, 6630 (2003)
(doi: 10.1021/ja035303i)

Enantioselective Total Synthesis of Aspidophytine


Shinjiro Sumi, Koji Matsumoto, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 5, 1891 (2003)
(doi: 10.1021/ol034445e)

Total Synthesis of Leustroducsin B


Kousei Shimada, Yosuke Kaburagi, and Tohru Fukuyama
J. Am. Chem. Soc., 125, 4048 (2003)
(doi: 10.1021/ja0340679)

Stereoselective Formation of aβ-Lactam Fused Oxathiazepin: A Synthetic Approach to Eudistomins

Tohru Yamashita, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 738 (2003)
(doi: 10.1055/s-2003-38378)

Transformation of Primary Amines to N-Monoalkylhydroxylamines: N-Hydroxy-(S)-phenylethylamine Oxalate

Hidetoshi Tokuyama, Takeshi Kuboyama and Tohru Fukuyama
Org. Synth., 80, 207 (2003)
[link]

Stereocontrolled Total Synthesis of (+)-Vinblastine


Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama and Tohru Fukuyama
Pure Appl. Chem., 75, 29 (2003)
(doi: 10.1351/pac200375010029)


2002


Preparation of Secondary Amines from Primary Amines via 2-Nitrobenzenesulfonamides: N-(4-Methoxybenzyl)-3-phenylpropylamine

Wataru Kurosawa, Toshiyuki Kan and Tohru Fukuyama
Org. Synth., 79, 186 (2002)
[link]

Facile Construction of N-Hydroxybenzazocine: Enantioselective Total Synthesis of (+)-FR900482


Masashi Suzuki, Mika Kambe, Hidetoshi Tokuyama and Tohru Fukuyama
Angew. Chem. Int. Ed., 41, 4686 (2002)
(doi: 10.1002/anie.200290016)

Highly Versatile Synthesis of Polyamines by the Ns-strategy on a Novel Trityl Chloride Resin

Toshiyuki Kan, Hideki Kobayashi and Tohru Fukuyama
Synlett, 1338 (2002)
(doi: 10.1055/s-2002-32976)

Synthetic Approach to Tetrodotoxin

Tetsuji Itoh, Manabu Watanabe and Tohru Fukuyama
Synlett, 1323 (2002)
(doi: 10.1055/s-2002-32984)

Efficient Macrocyclization by Means of 2-Nitrobenzenesulfonamide and Total Synthesis of Lipogrammistin-A


Toshiyuki Kan, Akiko Fujiwara, Hideki Kobayashi and Tohru Fukuyama
Tetrahedron, 58, 6267 (2002)
(doi: 10.1016/S0040-4020(02)00626-9)

Reduction of Ethanethiol Esters to Aldehydes

Hidetoshi Tokuyama, Satoshi Yokoshima, Shao-Cheng Lin, Leping Li and Tohru Fukuyama
Synthesis, 1121 (2002)
(doi: 10.1055/s-2002-31969)

Total Synthesis of Ecteinascidin 743


Atsushi Endo, Arata Yanagisawa, Masanao Abe, Shigemitsu Tohma, Toshiyuki Kan and Tohru Fukuyama
J. Am. Chem. Soc., 124, 6552 (2002)
(doi: 10.1021/ja026216d)

Efficient Synthesis of Medium-Sized Cyclic Amines by Means of 2-Nitrobenzenesulfonamide

Toshiyuki Kan, Hideki Kobayashi and Tohru Fukuyama
Synlett, 697 (2002)
(doi: 10.1055/s-2002-25369)

Stereocontrolled Total Synthesis of (+)-Vinblastine


Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama and Tohru Fukuyama
J. Am. Chem. Soc., 124, 2137 (2002)
(doi: 10.1021/ja0177049)

A Novel Conversion of α-Aminonitrile to Amide

Satoshi Yokoshima, Tetsuji Kubo, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Lett., 122 (2002)
(doi: 10.1246/cl.2002.122)

A Mild Copper-Mediated Intramolecular Amination of Aryl Halides

Ken Yamada, Testuji Kubo, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 231 (2002)
(doi: 10.1055/s-2002-19782)

Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization of 2-Alkenylphenylisocyanide

Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Rec., 2, 37 (2002)
(doi: 10.1002/tcr.10008)

One-Pot Claisen Rearrangement with n-Butyl Vinyl Ether

Hidetoshi Tokuyama, Takaaki Makido, Toshihiro Ueda and Tohru Fukuyama
Synth. Commun., 32, 869 (2002)
(doi: 10.1081/SCC-120002696)

Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization with Hypophosphorous Acid and Its Application to Total Synthesis of (±)-Catharanthine


Matthew T. Reding, Yosuke Kaburagi, Hidetoshi Tokuyama and Tohru Fukuyama
Heterocycles, 56, 313 (2002)
(doi: 10.3987/COM-01-S(K)42)


2001


Highly Versatile Synthesis of Nitrogen-Containing Compounds by Means of Nitrobenzenesulfonamides

Toshiyuki Kan and Tohru Fukuyama
J. Synth. Org. Chem., Jpn., 59, 779 (2001)

Synthesis of Optically Active α-Arylglycines: Stereoselective Mannich Reaction of Phenols with a New Chiral Template

Shigemitsu Tohma, Atsushi Endo, Toshiyuki Kan and Tohru Fukuyama
Synlett, 1179 (2001)
(doi: 10.1055/s-2001-15168)

A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones

Hidetoshi Tokuyama, Manabu Watanabe, Yuki Hayashi, Toshiki Kurokawa, Ge Peng and Tohru Fukuyama
Synlett, 1403 (2001)
(doi: 10.1055/s-2001-16808)

Intramolecular 1,3-Dipolar Cycloaddition Strategy for Enantioselective Synthesis of FR-900482 Analogues

Mika Kambe, Eri Arai, Masashi Suzuki, Hidetoshi Tokuyama and Tohru Fukuyama
Org. Lett., 3, 2575 (2001)
(doi: 10.1021/ol016243t)

A Practical Route to Quinolines from Anilines

Hidetoshi Tokuyama, Masashi Sato, Toshihiro Ueda and Tohru Fukuyama
Heterocycles, 54, 105 (2001)
(doi: 10.3987/COM-00-S(I)63)


2000


Enantioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration


Satoshi Yokoshima, Hidetoshi Tokuyama and Tohru Fukuyama
Angew. Chem. Int. Ed., 39, 4073 (2000)
(doi: 10.1002/1521-3773(20001117)39:22<4073::AID-ANIE4073>3.0.CO;2-V)

Total Synthesis of Lipogrammistin-A


Akiko Fujiwara, Toshiyuki Kan and Tohru Fukuyama
Synlett, 1667 (2000)
(doi: 10.1055/s-2000-7950)

Total Synthesis of Polyamine Toxin HO-416b and Agel-489 Using a 2-Nitrobenzenesulfonamide Strategy


Yuko Hidai, Toshiyuki Kan and Tohru Fukuyama
Chem. Pharm. Bull., 48, 1570 (2000)
(doi: 10.1248/cpb.48.1570)

Total Synthesis of (−)-CP-263,114 (Phomoidride B)


J. Am. Chem. Soc., 122, 7825 (2000)
(doi: 10.1021/ja001664b)

A Novel Transformation of Primary Amines to N-Monoalkylhydroxylamines

Hidetoshi Tokuyama, Takeshi Kuboyama, Akiko Amano, Tohru Yamashita and Tohru Fukuyama
Synthesis, 1299 (2000)
(doi: 10.1055/s-2000-6428)

An Efficient Total Synthesis of (−)-Vindoline


Satoshi Kobayashi, Toshihiro Ueda and Tohru Fukuyama
Synlett, 883 (2000)
(doi: 10.1055/s-2000-6724)

Synthesis of 2,3-Disubstituted Indoles by Palladium-Mediated Coupling of 2-Iodoindoles

Hidetoshi Tokuyama, Yosuke Kaburagi, Xiaoqi Chen and Tohru Fukuyama
Synthesis, 429 (2000)
(doi: 10.1055/s-2000-6354)


1999


Stereocontrolled Total Synthesis of (±)-Catharanthine via Radical-Mediated Indole Formation


Matthew T. Reding and Tohru Fukuyama
Org. Lett., 1, 973 (1999)
(doi: 10.1021/ol990749i)

N-Carboalkoxy-2-Nirobenzenesulfonamides: A Practical Preparation of N-Boc-, N-Alloc-, and N-Cbz-Protected Primary Amines

Tohru Fukuyama, Mui Cheung and Toshiyuki Kan
Synlett, 1301 (1999)
(doi: 10.1055/s-1999-2827)

Stereocontrolled Total Synthesis of (+)-K252a


Yoshihisa Kobayashi, Teppei Fujimoto and Tohru Fukuyama
J. Am. Chem. Soc., 121, 6501 (1999)
(doi: 10.1021/ja990909l)

Synthetic Study on Ecteinascidin 743 Starting from D-Glucose


Atsushi Endo, Toshiyuki Kan and Tohru Fukuyama
Synlett, 1103 (1999)
(doi: 10.1055/s-1999-3161)

Total Synthesis of Polyamine Toxin HO-416b Utilizing the 2-Nitrobenzenesulfonamide Protecting Group


Yuko Hidai, Toshiyuki Kan and Tohru Fukuyama
Tetrahedron Lett., 40, 4711 (1999)
(doi: 10.1016/S0040-4039(99)00851-5)

Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles

Hidetoshi Tokuyama, Tohru Yamashita, Matthew T. Reding, Yosuke Kaburagi and Tohru Fukuyama
J. Am. Chem. Soc., 121, 3791 (1999)
(doi: 10.1021/ja983681v)

Efficient Total Syntheses of (±)-Vincadifformine and (−)-Tabersonine


Satoshi Kobayashi, Ge Peng and Tohru Fukuyama,
Tetrahedron Lett., 40, 1519 (1999)
(doi: 10.1016/S0040-4039(98)02667-7)


1998


Synthetic Studies on CP-225,917 and CP-263,114

Nobuaki Waizumi, Tetsuji Itoh and Tohru Fukuyama
Tetrahedron Lett., 39, 6015 (1998)
(doi: 10.1016/S0040-4039(98)01236-2)

A Novel Ketone Synthesis by a Palladium-Catalyzed Reaction of Thiol Esters and Organozinc Reagents

Hidetoshi Tokuyama, Satoshi Yokoshima, Tohru Yamashita and Tohru Fukuyama
Tetrahedron Lett., 39, 3189 (1998)
(doi: 10.1016/S0040-4039(98)00456-0)

2-(2-Aminophenyl)-acetaldehyde Dimethyl Acetal: A Novel Reagent for the Protection of Carboxylic Acids

Eri Arai, Hidetoshi Tokuyama, M. S. Linsell and Tohru Fukuyama
Tetrahedron Lett., 39, 71 (1998)
(doi: 10.1016/S0040-4039(97)10491-9)


1997


2,4-Dinitrobenzenesulfonamides: A Simple and Practical Method for the Preparation of Secondary Amines and Diamines

Tohru Fukuyama, Mui Cheung, Chung-Kuang Jow, Yuko Hidai and Toshiyuki Kan
Tetrahedron Lett., 38, 5831 (1997)
(doi: 10.1016/S0040-4039(97)01334-8)

Stereocontrolled Total Synthesis of (±)-Gelsemine


Tohru Fukuyama and Gang Liu
Pure Appl. Chem., 69, 501 (1997)
(doi: 10.1351/pac199769030501)


1996


Stereocontrolled Total Synthesis of (±)-Gelsemine


Tohru Fukuyama and Gang Liu
J. Am. Chem. Soc., 118, 7426 (1996)
(doi: 10.1021/ja961701s)


1995


2- and 4- Nitrobenzenesulfonamides: Exceptionally Versatile Means for Preparation of Secondary Amines and Protection of Amines

Tohru Fukuyama, Chung-Kuang Jow and Mui Cheung
Tetrahedron Lett., 36, 6373 (1995)
(doi: 10.1016/0040-4039(95)01316-A)


1994


Total Synthesis of (+)-Leinamycin


Tohru Fukuyama and Yutaka Kanda
J. Synth. Org. Chem., Jpn., 52, 888 (1994)

Use of 1,1,1,3,3,3-Hexamethyldisilazane and N,O-Bis(trimethylsilyl)acetaamide in Aromatic Claisen Rearrangement: An Efficient Method for Preventing Abnormal Claisen Rearrangement

Tohru Fukuyama, Tangqing Li and Ge Peng
Tetrahedron Lett., 35, 2145 (1994)
(doi: 10.1016/S0040-4039(00)76781-5)

A Novel Tin-Mediated Indole Synthesis

Tohru Fukuyama, Xiaoqi Chen and Ge Peng
J. Am. Chem. Soc., 116, 3127 (1994)
(doi: 10.1021/ja00086a054)

Stereocontrolled Synthesis of (−)-Hapalindole G


Tohru Fukuyama and Xiaoqi Chen
J. Am. Chem. Soc., 116, 3125 (1994)
(doi: 10.1021/ja00086a053)


1993


Total Synthesis of (+)-Leinamycin


Yutaka Kanda and Tohru Fukuyama
J. Am. Chem. Soc., 115, 8451 (1993)
(doi: 10.1021/ja00071a066)

Total Synthesis of (−)-Tantazole B


Tohru Fukuyama and Lianhong Xu
J. Am. Chem. Soc., 115, 8449 (1993)
(doi: 10.1021/ja00071a065)

Total Synthesis of Mitomycins


Tohru Fukuyama and Lihu Yang
"Studies in Natural Products Chemistry"
Ed. by Atta-ur-Rahman, Elsevier, Amsterdam, pp 433-472 (1993)

Total Synthesis of (+)-Porothramycin B


Tohru Fukuyama, Gang Liu, Steven D. Linton, Shao-Cheng Lin and Hiroshi Nishino
Tetrahedron Lett., 33, 2577 (1992)
(doi: 10.1016/S0040-4039(00)77629-5)


1992


Synthesis of Naphthyridinomycin


Tohru Fukuyama
"Advances in Heterocyclic Natural Products Synthesis"
Ed. by W. H. Person, JAI Press, pp 189-249 (1992)

Synthetic Studies on Leinamycin. A Synthesis of 1-Oxo-1,3-dithiolan-3-one Moiety


Yutaka Kanda, Hiromitsu Saito and Tohru Fukuyama
Tetrahedron Lett., 33, 5701 (1992)
(doi: 10.1016/0040-4039(92)89010-A)

Total Synthesis of (±)-FR-900482


Tohru Fukuyama, Lianhong Xu and Shunsuke Goto
J. Am. Chem. Soc., 114, 383 (1992)
(doi: 10.1021/ja00027a071)


1990


Facile Reduction of Ethyl Thiol Esters to Aldehydes: Application to a Total Synthesis of (+)-Neothramycin A Methyl Ether


Tohru Fukuyama, Shao Cheng Lin and Leping Li
J. Am. Chem. Soc., 112, 7050 (1990)
(doi: 10.1021/ja00175a043)

Total Synthesis of (±)-Renieramycin A


Tohru Fukuyama, Steven D. Linton and Min Min Tun
Tetrahedron Lett., 31, 5989 (1990)
(doi: 10.1016/S0040-4039(00)98010-9)

Total Synthesis of (±)-Saframycin A


Tohru Fukuyama, Lihu Yang, Karen L. Ajeck and Richard A. Sachleben
J. Am. Chem. Soc., 112, 3712 (1990)
(doi: 10.1021/ja00165a095)


1980s


Practical Total Synthesis of (±)-Mitomycin C


Tohru Fukuyama and Lihu Yang
J. Am. Chem. Soc., 111, 8303 (1989)
(doi: 10.1021/ja00203a055)

Stereocontrolled Total Synthesis of (±)-Quinocarcin


Tohru Fukuyama and Joseph J. Nunes
J. Am. Chem. Soc., 110, 5196 (1988)
(doi: 10.1021/ja00223a052)

Total Synthesis of (±)-Mitomycins via Isomitomycin A


Tohru Fukuyama and Lihu Yang
J. Am. Chem. Soc., 109, 7881 (1987)
(doi: 10.1021/ja00259a046)

Stereocontrolled Total Synthesis of (±)-Cyanocycline A


Tohru Fukuyama, Leping Li, Alison A. Laird and R. Keith Frank
J. Am. Chem. Soc., 109, 1587 (1987)
(doi: 10.1021/ja00239a059)

Stereocontrolled Total Synthesis of (±)-Saframycin B


Tohru Fukuyama and Richard A. Sachleben
J. Am. Chem. Soc., 104, 4957 (1982)
(doi: 10.1021/ja00382a042)

Total Synthesis of (±)-Methyl 3-(3-Isocyano-6-oxabicyclo[3.1.0]hex-2-en-5-yl)-2-propenoate


Tohru Fukuyama and Yat Ming Yung
Tetrahedron Lett., 22, 3759 (1981)
(doi: 10.1016/S0040-4039(01)82013-X)

Total Synthesis of dl-Antibiotic 593A


Tohru Fukuyama, R. Keith Frank and Charles F. Jewell Jr.
J. Am. Chem. Soc., 102, 2122 (1980)
(doi: 10.1021/ja00526a076)


Corrections


Corrigendum: Total Synthesis of Tryprostatins A and B

Takayuki Yamakawa, Eiji Ideue, Jun Shimokawa and Tohru Fukuyama
Angew. Chem. Int. Ed., 53, 8808 (2014)
(doi: 10.1002/anie.201401055)

Corrigendum: Total Synthesis of (−)-Lycoposerramine-S

Naoaki Shimada, Yuzo Abe, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed., 53, 8808 (2014)
(doi: 10.1002/anie.201311008)

Correction to Total Synthesis of Lysergic Acid

Satoshi Umezaki, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 4692 (2014)
(doi: 10.1021/ol502316x)

Corrigendum: Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton

Kotaro Iwasaki, Rentaro Kanno, Toshiharu Morimoto, Tohru Yamashita, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed., 53, 3768 (2014)
(doi: 10.1002/anie.201401113)

Correction to "Total Synthesis of Ecteinascidin 743"

Fumiki Kawagishi, Tatsuya Toma, Tomohiko Inui, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 136, 5815 (2014)
(doi: 10.1021/ja502534m)

Correction to "Total Synthesis of (−)-Mersicarpine"

Rie Nakajima, Tsuyoshi Ogino, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 136, 5816 (2014)
(doi: 10.1021/ja502536z)

Correction to "Total Syntheses of Lyconadins A-C"

Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 136, 5817 (2014)
(doi: 10.1021/ja5025386)

Correction to "Concise Total Synthesis of (+)-Lyconadin A"

Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 136, 5818 (2014)
(doi: 10.1021/ja502539r)

Correction to (1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids

Takuya Nishimura, Kouhei Yamada, Tohru Takebe, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 1268 (2014)
(doi: 10.1021/ol403738z)

Correction to Total Synthesis of Lysergic Acid

Satoshi Umezaki, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 1269 (2014)
(doi: 10.1021/ol500159h)

Correction to Total Synthesis of (−)-Huperzine A

Takahiro Koshiba, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 1270 (2014)
(doi: 10.1021/ol500160t)

Correction to Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework

Yoichi Kita, Tatsuya Toma, Toshiyuki Kan and Tohru Fukuyama
Org. Lett., 16, 1271 (2014)
(doi: 10.1021/ol500161f)

Correction to 2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide

Masaya Fujii, Takuya Nishimura, Takahiro Koshiba, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 1272 (2014)
(doi: 10.1021/ol500162b)

Correction to Total Synthesis of (−)-Histrionicotoxin

Yohei Adachi, Noriyuki Kamei, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 16, 1273 (2014)
(doi: 10.1021/ol5001632)