2024
97. Switching between P-acylation and O-acylation of H-phosphonates with
chloroformates by changing acyl pyridinium and acyl ammonium ions
in a microflow reactor
H. Kitamura, Y. Tanaka, S. Fuse
Chem. Commun. advance article
published Aug 27 2024 DOI: 10.1039/D4CC02871F
96. One-step syntheses of diaza-dioxa-fenestranes via the sequential (3+2)
cycloadditions of linear precursors and their structural analyses
S. Fuse, H. Ishikawa, H. Kitamura, H. Masui, T. Takahashi
Nat. Commun. 15, 6087, (2024).
published Jul 19 2024 DOI: 10.1038/s41467-024-49935-1
95. Rapid and mild nucleophilic substitution of highly active (indol-2-yl)methyl
electrophile in a microflow reactor
S. Fuse, Y. Matsuura, N. Yamasaki
Synthesis 56, (17), 2663-2669, (2024).
published Jun 13 2024 DOI: 10.1055/s-0043-1775370
94. Effect of Brønsted acids on the activation of mixed anhydride/mixed carbonic
anhydride and C-terminal-free N-methylated peptide synthesis in a micro-flow
reactor
T-H. Chen, A. Ando, O. Shamoto, S. Fuse,
Chem. Eur. J. 30, (38), e202401402, (2024).
published May 08 2024 DOI: 10.1002/chem.202401402
Highlighted in Synfacts 09/2024
Selected as Synfact of the Month
93. Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and
nucleophilic addition in a microflow reactor
Y. Matsuura, S. Fuse,
Org. Biomol. Chem. 22, (17), 3448-3452 (2024).
published Apr. 10 2024 DOI: 10.1039/D4OB00358F
92. Microflow, sequential coupling and cyclization approach for synthesis
of cyclic phosphotriesters from PCl3
K. Nakabayashi, H. Kitamura, S. Fuse
Chem. Asian J. 19, (11), e202400256, (2024).
published Mar. 31 2024 DOI: 10.1002/asia.202400256
91. Facile generation of t-butoxycarbonyl chloride equivalent and its use in
micro-flow reactor
K. Miyamoto, R. Okabe, S. Fuse,
Org. Process Res. Dev. 28, (5), 1971-1978 (2024).
published Apr. 8 2024 DOI: 10.1021/acs.oprd.4c00009
90. Micro-flow heteroatom alkylation via TfOH-mediated rapid in situ generation of
carbocations and subsequent nucleophile addition
Y. Matsuura, S. Fuse,
Chem. Commun. 60, 2497-2500 (2024).
published Jan. 29 2024 DOI: 10.1039/D3CC06308A
Inside Back Cover Picture
89. Micro-flow synthesis of unsymmetrical H-phosphonates via sequential and
direct substitution of chlorine atoms in phosphorus trichloride with alkoxy
groups
Y. Tanaka, H. Kitamura, S. Fuse,
J. Org. Chem. 89, (3), 1777-1783 (2024).
published Jan. 1 2024 DOI: 10.1021/acs.joc.3c02467
2023
88. Multi-objective Bayesian optimisation using q-Noisy Expected
Hypervolume Improvement (qNEHVI) for Schotten-Baumann reaction
J. Zhang, N. Sugisawa, K. C. Felton, S. Fuse, A. A. Lapkin,
React. Chem. Eng. 9 (3), 706-712, (2024).
published Dec. 1 2023 DOI: 10.1039/D3RE00502J
87. One flow synthesis of substituted indoles via sequential
1,2-addition/nucleophilic substitution of indolyl-3-carbaldehydes
S. Fuse, S. Kanda, H. Masui,
Chem. Asian J. 19, (1), e202300909 (2024).
published Nov. 14 2023 DOI: 10.1002/asia.202300909
86. Switchable synthesis of 7- and 14-membered cyclic peptides containing
N-methyl- and β-amino acids utilizing micro-flow technology
S. Fuse, R. Okabe,
Eur. J. Org. Chem. 26, (35), e202300700 (2023).
published Jul. 18 2023 DOI: 10.1002/ejoc.202300700
85. One-flow syntheses of unsymmetrical sulfamides and N-substituted
sulfamate esters
N. Sugisawa, K. Nakabayashi, H. Sugisawa, S. Fuse,
Org. Lett. 26, (14), 2739-2744 (2024).
published Jun. 13 2023 DOI: 10.1021/acs.orglett.3c01546
84. Rapid and column-chromatography-free peptide chain elongation via a
one-flow, three-component coupling approach
N. Sugisawa, A. Ando, S. Fuse,
Chem. Sci. 14, (25), 6986-6991 (2023).
published Jun. 12 2023 DOI: 10.1039/D3SC01333B
Highlighted in Org. Process Res. Dev.
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Selected as Synfact of the Month
83. Peptide cyclization by the use of acylammonium species
O. Shamoto, K. Komuro, N. Sugisawa, T-H. Chen, H. Nakamura, S. Fuse,
Angew. Chem. Int. Ed. 62, (27), e202300647, (2023).
published May 10 2023 DOI: 10.1002/anie.202300647
Highlighted in Synfacts 08/2023
Selected as Synfact of the Month
日経電子版掲載（令和5年5月18日）
Highlighted on the cover picture
of Synfacts 08/2023
82. Verification of the previous synthesis for (1H-indol-3-yl)methyl halide and
development of its rapid generation and nucleophilic substitution method
H. Masui, S. Kanda, S. Fuse
Commun. Chem. 6, 47, (2023).
published Mar. 4 2023 DOI: 10.1038/s42004-023-00837-1
日刊工業新聞掲載（令和5年3月10日）
81. Liquid-phase continuous-flow peptide synthesizer for preparing C-terminal
free peptides
Y. Otake, K. Adachi, Y. Yamashita, N. Iwanaga, H. Sunakawa, T. Shamoto,
J. Ogawa, A. Ito, Y. Kobayashi, K. Masuya, S. Fuse, D. Kubo, H. Ito
React. Chem. Eng. 8 (4) 863-870 (2023).
published Dec. 16 2022 DOI: 10.1039/D2RE00453D
2022
80. Sequential nucleophilic substitution of phosphorus trichloride with alcohols in a
continuous-flow reactor and consideration of a mechanism for reduced
overreaction via the addition of imidazole
H. Kitamura, Y. Otake, N. Sugisawa, H. Sugisawa, T. Ida, H. Nakamura, S. Fuse
Chem. Eur. J. 28, (37), e202200932, (2022).
published Jun. 13 2022 DOI: 10.1002/chem.202201646
Highlighted in Synfacts 08/2022
Inside Front Cover Picture
79. Micro-flow rapid dual activation approach for the urethane-protected α-amino acid
N-carboxy anhydride synthesis,
R. Okabe, N. Sugisawa, S. Fuse,
Org. Biomol. Chem. 20, (16), 3303-3310, (2022).
published Mar. 1 2022 DOI: 10.1039/D2OB00167E
Highlighted in Synfacts 06/2022
Inside Front Cover Picture
Inside Front Cover Picture
2021
78. Rapid and mild one-flow synthetic approach to unsymmetrical sulfamides guided by
Bayesian optimization,
N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse,
Chem. Methods 1, (11), 484-490, (2021).
published Aug. 18 2021 DOI: 10.1002/cmtd.202100053
日刊工業新聞掲載（令和3年9月2日）
77. Rapid and mild lactamization using highly electrophilic triphosgene in
a micro-flow reactor,
S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura,
Chem. Eur. J. 27, (27), 7525-7532 (2021).
published Jan. 26 2021 DOI: 10.1002/chem.202100059
Inside Front Cover Picture
2020
76. Size-controllable and scalable production of liposomes using a V-shape
mixer micro-flow reactor,
J. Kawamura, H. Kitamura, Y. Otake, S. Fuse, H. Nakamura,
Org. Process Res. Dev. 24, (10), 2122-2127 (2020).
published Jun. 5 2020 DOI: 10.1021/acs.oprd.0c00174
75. Investigation into the influence of an acrylic acid acceptor in organic
D-π-A sensitizers against phototoxicity
S. Fuse, W. Moriya, S. Sato, H. Nakamura,
Bioorg. Med. Chem. 28, (13), 115558 (2020).
published May 19 2020 DOI: 10.1016/j.bmc.2020.115558
74. Photochemical conversion of isoxazoles to 5-hydroxyimidazolines
T. Morita, S. Fuse, H. Nakamura
Org. Lett. 22, (9), 3460-3463 (2020).
published Apr. 14 2020 DOI: 10.1021/acs.orglett.0c00910
73. N-Methylated peptide synthesis via acyl N-methylimidazolium cation
generation accelerated by a Brønsted acid
Y. Otake, Y. Shibata, Y. Hayashi, S. Kawauchi, H. Nakamura, S. Fuse,
Angew. Chem. Int. Ed. 59, (31), 12925-12930 (2020).
published Apr. 9 2020 DOI: 10.1002/anie.202002106
Highlighted in Synfacts 07/2020
Selected as Synfact of the Month
72. Micro-flow synthesis of β-amino acid derivatives via a rapid dual
activation approach,
N. Sugisawa, H. Nakamura, S. Fuse,
Chem. Commun. 56, 4527-4530 (2020).
published Apr. 3 2020 DOI: 10.1039/D0CC01403F
Outside Back Cover Picture
71. Single-step, rapid, and mild synthesis of β-amino acid N-carboxy
anhydrides using micro-flow technology,
N. Sugisawa, Y. Otake, H. Nakamura, S. Fuse,
Chem. Asian J. 15, (1), 79-84 (2020).
published Nov. 28 2019 DOI: 10.1002/asia.201901429
This manuscript was also published in
The special collection for the 100th CSJ Annual Meeting.
Inside Front Cover Picture
名古屋大学布施研究室発足前の原著論文リストはこちら
Original papers before moving to Nagoya University, see