小坂田文隆准教授の代表的業績
(1) Cruz-Martin A, El-Danaf R, Osakada F, Sriram B, Dhande O, Nguyen P, Callaway EM, Ghosh A and Huberman A
A dedicated circuit linking direction selective retinal ganglion cells to primary visual cortex.
Nature. 507: 358-361 (2014)
(2) Osakada F and Callaway EM.
Design and generation of recombinant rabies virus vectors.
Nature Protoc. 8: 1583-1601 (2013)
(3) Osakada F, Mori T, Cetin AH, Marshel JH, Virgen B and Callaway EM
New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits.
Neuron. 71: 617-631 (2011)
(4) Osakada F, Ikeda H, Sasai Y and Takahashi M
Stepwise differentiation of pluripotent stem cells into retinal cells.
Nature Protoc. 4: 811-824 (2009)
(5) Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Sasai Y and Takahashi M
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells.
Nature Biotechnol., 26, 215-352 (2008)
森本菜央助教の代表的業績
(1) Morimoto-Suzuki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H and Gotoh Y
The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.
Development, 141(22), 4343-53 (2014) Selected by "Faculty of 1000"
(2) Hirabayashi Y, Suzki N, Tsuboi M, Endo T.A., Toyoda T, Shinga J, Koseki H, Vidal M, and Gotoh Y
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.
Neuron, 63, 600-613 (2009)
論文一覧
【学術論文】
Yuji Masaki, Masahiro Yamaguchi, Ryosuke F Takeuchi, Fumitaka Osakada.
Monosynaptic rabies virus tracing from projection-targeted single neurons
Neurosci Res. (2022) [Pubmed]
Arisa Ito, Ke Ye, Masanari Onda, Toshiaki Suzuki, Nao Morimoto, Fumitaka Osakada.
Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells
Biochem Biophys Res Commun. (2021) [Pubmed]
Masanari Onda, Ryosuke F Takeuchi, Keisuke Isobe, Toshiaki Suzuki, Yuji Masaki, Nao Morimoto, Fumitaka Osakada.
Temporally multiplexed dual-plane imaging of neural activity with four-dimensional precision
Neurosci Res. (2021) [Pubmed]
Sayumi Okigawa, Masahiro Yamaguchi, Kei N. Ito, Ryosuke F. Takeuchi, Nao Morimoto, Fumitaka Osakada.
Cell type- and layer-specific convergence in core and shell neurons of the dorsal lateral geniculate nucleus
Journal of Comparative Neurology. (2020) [Pubmed]
Ke Ye, Yuto Takemoto, Arisa Ito, Masanari Onda, Nao Morimoto, Michiko Mandai, Masayo Takahashi, Ryuji Kato, Fumitaka Osakada.
Reproducible production and image-based quality evaluation of retinal pigment epithelium sheets from human induced pluripotent stem cells
Scientific Reports. (2020) [Pubmed]
Toshiaki Suzuki, Nao Morimoto, Akinori Akaike, Fumitaka Osakada.
Multiplex neural circuit tracing with G-deleted rabies viral vectors.
Front Neural Circuits. (2019) [Pubmed]
Seirin-Lee S, Osakada F, Takeda J, Tashiro S, Kobayashi R, Yamamoto T, Ochiai H.
Role of dynamic nuclear deformation on genomic architecture reorganization.
PLoS Comput Biol. (2019) [Pubmed]
Dohaku R, Yamaguchi M, Yamamoto N, Shimizu T, Osakada F, Hibi M.
Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus.
Front Neural Circuits. (2019) [Pubmed]
Yetman MJ, Washburn E, Hyun JH, Osakada F, Hayano Y, Zeng H, Callaway EM, Kwon HB, Taniguchi H.
Intersectional monosynaptic tracing for dissecting subtype-specific organization of GABAergic interneuron inputs.
Nat Neurosci. (2019) [Pubmed]
Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ.
Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping.
Front Neuroanat. (2019) [Pubmed]
Kume T, Suenaga A, Izumi Y and Akaike A.
Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in Mice.
Biol Pharm Bull., 39(6):1055-9 (2016)
Fumitaka Osakada and Masayo Takahashi.
Stem Cells in the Developing and Adult Nervous System.
Regenerative Medicine - from Protocol to Patient. (2016)
Lauren Faget, Fumitaka Osakada, Jinyi Duan, Reed Ressler, Alexander B. Johnson, James A. Proudfoot, Ji Hoon Yoo, Edward M. Callaway and Thomas S. Hnasko.
Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area.
Cell Reports. (2016)
Krishnan Padmanabhan, Fumitaka Osakada, Anna Tarabrina, Erin Kizer, Edward M. Callaway, Fred H. Gage and Terrence J. Sejnowski.
Diverse Representations of Olfactory Information in Centrifugal Feedback Projections.
J.Neurosci. (2016) [Pubmed]
Ju Tian, Ryan Huang, Jeremiah Y. Cohen, Fumitaka Osakada, Dmitry Kobak, Christian K. Machens, Edward M. Callaway, Naoshige Uchida and Mitsuko Watabe-Uchida.
Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons.
Neuron. (2016) [Pubmed]
Xu C, Krabbe S, Grundemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schnitzer MJ, Callaway EM and Luthi A.
Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval.
Cell. (2016) [Pubmed]
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.
J Pharmacol Sci., 129(3):150-9. (2015) Fujimura K, Niidome T, Shinozuka Y, Izumi Y, Kihara T, Sugimoto H, Akaike A and Kume T.
Integrin-associated protein promotes neuronal differentiation of neural stem/progenitor cells.
PLoS One., 10, e0116741 (2015)
Osakada F and Takahashi M
Challenges in retinal circuit regeneration: linking neuronal connectivity to circuit function.
Biol Pharm Bull., 38(3), 341-57 (2015).
Tuncdemir SN, Wamsley B, Stam FJ, Osakada F, Goulding M, Callaway EM, Rudy B and Fishell G.
Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits.
Neuron.89(3):521-35 (2016)
【総説・解説】
平井 宏和，日置 寛之，小林 和人／編
実験医学別冊 決定版 ウイルスベクターによる遺伝子導入実験ガイド
羊土社 (2020) [Web]
竹内 遼介, 小坂田 文隆
空間視知覚と視覚誘導性行動を支える神経回路メカニズム
日薬理誌 (2020) [J-STAGE]
山口 真広, 森本 菜央, 小坂田 文隆
狂犬病ウイルスベクターを用いた神経回路解析法
バイオイノベーションに向けて ～バイオテクノロジーの新技術からの新しい視点～ 237-246 (2019)
シーエムシー出版 (2019) [Web]
脳内のドパミンの挙動を可視化するdLight1
ファルマシア Vol. 55 No. 2 (2019) 伊藤 ありさ , 葉 珂 , 小坂田 文隆
iPS細胞・再生医療 iPS細胞由来網膜色素上皮細胞から観た再生医療等製品の開発
Pharm stage 18(7), 2-7, 2018-10 (2018) 恩田 将成, 三澤 幸樹, 小坂田 文隆
網膜神経回路を解析するウイルス遺伝子工学と電気生理学的手法
YAKUGAKU ZASSHI (2018) [Pubmed]
小坂田 文隆, 小池 千恵子
網膜における生理・病態解明と治療開発への新展開
YAKUGAKU ZASSHI (2018) [Pubmed]
恩田 将成, 小坂田 文隆
視覚情報処理を担う神経回路の構造と機能
日薬理誌 (2017) [Pubmed]
小坂田 文隆
網膜再生治療に向けた新規幹細胞由来網膜細胞作成法の開発と創薬への応用
YAKUGAKU ZASSHI (2017) [Pubmed]
赤池昭紀．
奨励賞受賞 小坂田文隆氏の業績 ．
ファルマシア Vol. 52(2016) No. 6
鈴木俊章，小坂田文隆
マウスを用いた視覚研究と抑制性神経回路の最前線
日薬理誌 (2016)
荒川大二朗，伊藤ありさ，小坂田文隆
ヒトiPS細胞由来網膜色素上皮細胞を用いた新規治療法の開発
日薬理誌 (2016)
小坂田 文隆
網膜再生治療に向けた新規幹細胞由来網膜細胞作成法の開発と創薬への応用
YAKUGAKU ZASSHI (2017) [Pubmed]
大脳皮質の層ごとに異なる方向選択性をもつ機能単位の発見．
実験医学, 33(16), 2600-2601 (2015)
小坂田文隆
新規手法が切り拓く神経回路研究の新時代
化学と生物, 53(10), 673-680 (2015)
小坂田文隆
神経回路の構造と機能を明らかにする新規G欠損狂犬病ウイルストレーシング法
日薬理誌, 146(2), 98-105 (2015)
【受賞】
小坂田文隆
「光科学技術研究振興財団 研究表彰」
受賞研究「光の検出および情報伝達の再構築を目指した網膜再生研究」
「日本薬学会奨励賞」
受賞研究「網膜再生治療に向けた新規幹細胞由来網膜細胞作成法の開発と創薬への応用」
http://www.pharm.or.jp/prize/award16.shtml 小坂田文隆
「日本薬理学会 第31回学術奨励賞」
受賞研究「新規狂犬病ウイルストレーシング法による神経回路の構造・機能・再生の解明」
http://www.pharmacol.or.jp/oshirase/award/bounty01.htm
【メディア】
小坂田文隆
日経バイオテク7月13日号「若手研究者の肖像」（第4回）
https://bio.nikkeibp.co.jp/article/news/20150716/186309/