名古屋大学大学院創薬科学研究科　創薬有機化学講座

2020

• Theoretical Study of the Mechanism of Palladium(0)-Catalyzed Intramolecular [2+2+2] Cycloaddition of Ester-Substituted Alkynes
  Yoshihiko Yamamoto
  Eur. J. Org. Chem. 2020, 7455-7465.
• Rhodium-Catalyzed Cycloisomerization of Ester-Tethered 1,6-Diynes with Cyclopropanol Moiety Leading to Tetralone/Exocyclic Diene Hybrid Molecules
  Takeshi Yasui, Tomohiro Kikuchi, and Yoshihiko Yamamoto
  Chem. Commun. 2020, 56, 12865-12868.
• Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine
  Haruki Inada, Masatoshi Shibuya, and Yoshihiko Yamamoto
  J. Org. Chem. 2020, 85, 11047-11059.
  [selected as a FEATURED ARTICLE]
  [Highlighted in Synfacts, 2020, 16(11)]
• Palladium-Catalyzed [3+2] and [2+2+2] Annulations of 4-Iodo-2-quinolones with Activated Alkynes through Selective C-H Activation
  Yoshihiko Yamamoto, Jiyue Jiang, Takeshi Yasui
  Chem. Eur. J. 2020, 26, 3749-3757.
  [Frontispiece; volume 26, issue 17]
• Nitroxyl Radical-Catalyzed Chemoselective Alcohol Oxidation for the Synthesis of Polyfunctional Molecules
  Masatoshi Shibuya
  Tetrahedron Lett. 2020, 61, 151515. (Digest paper)

2019

• One-pot, Two-step Synthesis of Unnatural alpha-Amino Acids Involving the Exhaustive Aerobic Oxidation of 1,2-Diols
  Haruki Inada, Keisuke Furukawa, Masatoshi Shibuya, Yoshihiko Yamamoto
  Chem. Commun. 2019, 55, 15105-15108.
  [Highlighted in Synfacts, 2020, 16(03)]
  
• Recent Advances in Transition-Metal-Catalyzed Synthesis of 3- and/or 4-Aryl-2(1H)-Quinolones
  Yoshihiko Yamamoto
  Heterocycles 2019, 98, 1309-1344.
  
• Diastereoselective Methylation at the Congested β-Position of a Butenolide Ring: Studies toward the Synthesis of seco-Prezizaane-Type Sesquiterpenes
  Tomoyoshi Kawamura, Hirokazu Moriya, Masatoshi Shibuya, and Yoshihiko Yamamoto
  J. Org. Chem. 2019, 84, 12508-12519.
• Tris(pentafluorophenyl)borane (Second Update)
  Masatoshi Shibuya
  Encyclopedia of Reagents for Organic Synthesis, Wiley Online Library, 2019
• Synthesis of (Difluoromethyl)cycloalkanes from 2-Cycloalkenones by Utilizing Phospha-Brook Rearrangement
  Yoshihiko Yamamoto, Yuki Ishida, Yosuke Takamizu, Takeshi Yasui
  Adv. Synth. Catal. 2019, 361, 3739-3743.
• Boron-Catalyzed Hydroamination/Hydroallylation and Hydroamination/Hydrocyanation of Unactivated Alkynes
  Masatoshi Shibuya, Shohei Kawano, Shoji Fujita, and Yoshihiko Yamamoto
  Asian J. Org. Chem. 2019, 8, 1075-1079.
• Selected Paper: Theoretical Study on the Transition-Metal-Catalyzed Cycloadditions of 2H-Azirines with Alkynes: Implication of Carbenoid Intermediates
  Yoshihiko Yamamoto
  Bull. Chem. Soc. Jpn. 2019, 92, 619-628.
  
• Direct Synthesis of Free alpha-Amino Acids by Telescoping Three-Step Process from 1,2-Diols
  [Highlighted in Synfacts, 2019, 15(04)]
  Haruki Inada, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Org. Lett. 2019, 21, 709-713.
• Synthesis of gamma-Difluoromethylated Tetronate Derivatives from Squarates Using Difluoromethylphosphonate
  Yoshihiko Yamamoto, Yuki Ishida, Takashi Kurohara, Masatoshi Shibuya, Takeshi Yasui
  Heterocycles 2019, 99, 363-378.
  

2018

• Theoretical Study of the Copper-Catalyzed Hydroarylation of (Trifluoromethyl)alkyne with Phenylboronic Acid
  Yoshihiko Yamamoto
  J. Org. Chem. 2018, 83, 12775-12783.
  [Cover; volume 83, issue 20]
• Discussion Addendum for: Stereoselective Synthesis of 3-Arylacrylates by Copper-Catalyzed Syn Hydroarylation [(E)-Methyl 3-phenyloct-2-enoate]
  Yoshihiko Yamamoto
  Org. Synth. 2018, 95, 267-275.
• Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway
  Takahide Hibi, Hokuto Ohtsuka, Takafumi Shimasaki, Shougo Inui, Masatoshi Shibuya, Hideki Tatsukawa, Kei Kanie, Yoshihiko Yamamoto, Hirofumi Aiba
  Genes Cells 2018, 23, 620-637.
• Synthesis of pyrroles via ruthenium-catalyzed nitrogen-transfer [2+2+1] cycloaddition of α,ω-diynes using sulfoximines as nitrene surrogates
  Kazuma Matsui, Masatoshi Shibuya, Yoshihiko Yamamoto
  Commn. Chem. 2018, 1, 21.
• Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes
  Masatoshi Shibuya, Masaki Okamoto, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto
  ACS Catal. 2018, 8, 4189-4193.
• Selected Paper: Combined Experimental and Computational Study on Catalytic Cyclocoupling of Epxides and CO₂ Using Porphyrin-Based Cu(II) Metal-Organic Frameworks with 2D Coordination Networks
  Tsukasa Murayama, Masayuki Asano, Tetsushi Ohmura, Arimitsu Usuki, Takeshi Yasui, Yoshihiko Yamamoto
  Bull. Chem. Soc. Jpn. 2018, 91, 383-390.
  
• Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarate and Their Transformations
  Takashi Kurohara, Jiang Jiyue, Masatoshi Shibuya, Yoshihiko Yamamoto
  Synthesis 2018, 1687-1698.
• Transfer Hydrogenation of Nitrogen Heterocycles Using a Recyclable Rhodium Catalyst Immobilized on Bipyridine-Periodic Mesoporous Organosilica
  Kazuma Matsui, Yoshifumi Maegawa, Minoru Waki, Shinji Inagaki, Yoshihiko Yamamoto
  Catal. Sci. Technol. 2018, 8, 534-539.
  
• The Vinylogous Catellani Reactions: A Combined Computational and Experimental Study
  Yoshihiko Yamamoto, Tsukasa Murayama, Jiyue Jiang, Takeshi Yasui, Masatoshi Shibuya
  Chem. Sci. 2018, 9, 1191-1199.
  

2017

• Recent Topics of Cp*RuCl-Catalyzed Annulation Reactions
  Yoshihiko Yamamoto
  Tetrahedron Lett. 2017, 58, 3787-3794. (Digest paper)
• Combined Experimental and Computational Study on Ruthenium(II)-Catalyzed Reactions of Diynes with Aldehydes and N,N-Dimethylformamide
  Yoshihiko Yamamoto, Yuta Okude, Shota Mori, Masatoshi Shibuya
  J. Org. Chem. 2017, 82, 7964-7973.
• Synthesis of Fused Furans and Thiophenes via Ruthenium-Catalyzed Atom-Transfer [2+2+1] Cycloadditions of α,ω-Diynes
  Yoshihiko Yamamoto
  Synlett 2017, 28, 1250-1257. (Account)
• Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System
  Shoji Fujita, Masatoshi Shibuya, Yoshihiko Yamamoto
  Synthesis 2017, 49, 4199-4204. (special topic)
• Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Endiynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion
  Yoshihiko Yamamoto, Kei-ichiro Nishimura, Shota Mori, Masatoshi Shibuya
  Angew. Chem. Int. Ed. 2017, 56, 5494-5497.
• 有機分子触媒を駆使するα-アミノ酸の不斉合成ー酵素反応にならった究極の人工酵素を目指して
  稲田大輝，澁谷正俊，山本芳彦
  化学. 2017, 72, 66-67.
• Bronsted Acid/Silane Catalytic System for Intramolecular Hydroalkoxylation and Hydroamination of Unactivated Alkynes
  Masatoshi Shibuya, Shoji Fujita, Masanori Abe, Yoshihiko Yamamoto
  ACS Catal. 2017, 7, 2848-2852.
  [Highlighted in Synfacts, 2017, 13(06)]
• Selective Aerobic Oxidation of Primary Alcohols to Aldehydes
  Masatoshi Shibuya, Keisuke Furukawa, Yoshihiko Yamamoto
  Synlett 2017, 28, 1554-1557. (cluster)
• Theoretical Study on Ruthenium-Catalyzed Hydrocarbomoylative Cyclization of 1,6-Diyne with Dimethylformamide
  Yoshihiko Yamamoto
  Organometallics 2017, 36, 1154-1163.
• Synthesis of 3-Aryl-2-(trifluoromethyl)indoles via Copper-Catalyzed Hydroarylation and Subsequent Cadogan Cyclization
  Yoshihiko Yamamoto, Erina Ohkubo, Masatoshi Shibuya
  Adv. Synth. Catal. 2017, 359, 1747-1751.
  [有機合成化学協会誌, 2017, 75(12) ”新しい合成”で紹介されました]
• The Anticancer Effects of Novel alpha-Bisabolol Derivatives Against Pancreatic Cancer
  Yoshihiko Murata, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tomohiro Niwa, Masatoshi Shibuya, Yoshihiko Yamamoto and Masato Nagino
  Anticancer Res. 2017, 37, 589-598.
• Electrophilic Derivatization of Trifluoromethyl-Substituted Semisquarate Using Unsaturated Organosilanes and Subsequent Ring Transformations
  Takashi Kurohara, Masatoshi Shibuya, Yoshihiko Yamamoto
  Adv. Synth. Catal. 2017, 359, 1413-1419.
• Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes
  Yoshihiko Yamamoto, Kei-ichiro Nishimura, Masatoshi Shibuya
  ACS Catal. 2017, 7, 1101-1107.
  [Highlighted in Synfacts, 2017, 13(03)]
• Editor's Choice: Ruthenium-Catalyzed Hydrocarbamoylative Cyclization of 1,6-Diynes with Formamides
  Shota Mori, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Chem. Lett. 2017, 46, 207-210.
  [有機合成化学協会誌, 2017, 75(8) ”新しい合成”で紹介されました]
• Synthesis of gamma-Trifluoromethyl Tetronate Derivatives from Squarates
  Yoshihiko Yamamoto, Yosuke Takamizu, Takashi Kurohara, Masatoshi Shibuya
  Heterocycles 2017, 95, 525-539.

2016

• Catalytic [2+2+1] Synthesis of Fused Thiophenes Using Thiocarbonyls as Sulfur Donors
  Kazuma Matsui, Masatoshi Shibuya, Yoshihiko Yamamoto
  Angew. Chem. Int. Ed. 2016, 55, 15397-15400.
• Divergent Synthesis of Polymethoxylated 4-Aryl-2-quinolones
  Tsukasa Murayama, Masatoshi Shibuya, and Yoshihiko Yamamoto
  J. Org. Chem. 2016, 81, 11940-11949.
• 有機ニトロキシラジカルの酸化還元特性を利用した効率的酸化システムの開発ー第一級アルコールからカルボン酸への酸化反応ー
  澁谷正俊
  有機合成化学協会誌 2016, 74, 965-974.

• Chemoselective Conversion from alpha-Hydroxy Acids to alpha-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation
  Keisuke Furukawa, Haruki Inada, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Org. Lett. 2016, 18，4230-4233.
• Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes
  Yoshihiko Yamamoto, Erina Ohkubo, and Masatoshi Shibuya
  Green Chem. 2016, 18, 4628-4632.
• Reagents for diverse iodosilane-mediated transformations
  Masatoshi Shibuya, Masanori Abe, Shoji Fujita, and Yoshihiko Yamamoto
  Org. Biomol. Chem. 2016, 14, 5322-5328.
• Synthesis of 4-Aryl-2-Quinolones via Copper-Catalyzed Hydroarylation of (o-Aminophenyl)propiolates with Arylboronates
  Tsukasa Murayama, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Adv. Synth. Catal. 2016, 358, 166-171.
  [Front Cover; volume 358, issue 2]

2015

• 生合成に着想を得たインドールアルカロイドの新規合成法
  川村智祥，山本芳彦
  化学と生物. 2015, 12，815-817.
• Ruthenium-Catalyzed Transfer Oxygenative [2 + 2 + 1]Cycloaddition of Silyldiynes Using Nitrones as Adjustable Oxygen Atom Donors: Synthesis of Bicyclic 2-Silylfurans
  Kazuma Matsui, Masatoshi Shibuya, and Yoshihiko Yamamoto
  ACS Catal. 2015, 5, 6468-6472.
• CF3-Substituted semisquarate: A pluripotent building block for the divergent synthesis of trifluoromethylated functional molecules
  Yoshihiko Yamamoto, Takashi Kurohara and Masatoshi Shibuya
  Chem. Commun. 2015, 51, 16357-16360.
  [Highlighted by ATLAS of Science]
• Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System
  Shoji Fujita, Masanori Abe, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Org. Lett. 2015, 17, 3822-3825.
• Hot Paper: A Combined Transition-Metal-Catalyzed and Photopromoted Process: Synthesis of 2,3-Fused 4-Phenylnaphthalen-1-yl Carboxylates from 1,7-Diaryl-1,6-diynes
  Yoshihiko Yamamoto, Shota Mori, and Masatoshi Shibuya
  Chem. Eur. J. 2015, 21, 9093-9100.
  [Inside Back Cover; volume 21, issue 25]
  [Highlighted by ATLAS of Science]
• Lactone-fused cyclohexadiene as versatile platform for diversified synthesis of 5,6,5-tricyclic scaffolds
  Masatoshi Shibuya, Tomonori Sudoh, Tomoyoshi Kawamura, and Yoshihiko Yamamoto
  Org. Biomol. Chem. 2015, 13, 5862-5866.
• Chemoselective Catalytic Oxidation of 1,2-Diols to alpha-Hydroxy Acids Controlled by TEMPO-ClO2 Charge-Transfer Complex
  Keisuke Furukawa, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Org. Lett. 2015, 17, 2282-2285.
• A Combined Experimental and Computational Study on the Cycloisomerization of 2-Ethynylbiraryls Catalyzed by Dicationic Arene Ruthenium Complexes
  Yoshihiko Yamamoto, Kazuma Matsui, and Masatoshi Shibuya
  Chem. Eur. J. 2015, 21, 7245-7255.
• Synthesis of 3,4-Fused 2-Quinolones from an (ortho-Aminophenyl)propiolate via Sequential Cycloaddition/Lactam Formation
  Tsukasa Murayama, Masatoshi Shibuya, and Yoshihiko Yamamoto
  Adv. Synth. Catal. 2015, 357, 690-694.
• Development of an Azanoradamantane-Type Nitroxyl Radical Catalyst for Class-Selective Oxidation of Alcohols
  Ryusuke Doi, Masatoshi Shibuya, Tsukasa Murayama, Yoshihiko Yamamoto, and Yoshihiaru Iwabuchi
  J. Org. Chem. 2015, 80, 401-413.

2014

• Mechanistic Insight into Aerobic Alcohol Oxidation Using NOx-Nitroxide Catalysis Based on Catalyst Structure-Activity Relationships
  Masatoshi Shibuya, Shota Nagasawa, Yuji Osada, and Yoshihiaru Iwabuchi
  J. Org. Chem. 2014, 79, 10256-10268.
• Synthesis of beta-Allylbutenolides via One-Pot Copper-Catalyzed Hydroallylation/Cyclization of gamma-Hydroxybutynoate Derivatives
  Yoshihiko Yamamoto, Shinya Shibano, Takashi Kurohara and Masatoshi Shibuya
  J. Org. Chem. 2014, 79, 4503-4511.
• Tandem Ruthenium-Catalyzed Transfer-Hydrogenative Cyclization/Intramolecular Diels-Alder Reaction of Enediynes Affording Dihydrocoumarin-Fused Polycycles
  Yoshihiko Yamamoto, Kazuma Matsui, and Masatoshi Shibuya
  Org. Lett. 2014, 16, 1806-1809.
  [Highlighted in Synfacts, 2014, 10(06)]
• Synthesis of Heterocycles via Transition-Metal-Catalyzed Hydroarylation of Alkynes
  Yoshihiko Yamamoto
  Chem. Soc. Rev. 2014, 43, 1575-1600.
  [ホットペーパー＆高被引用文献/Web of Science]

2013

• Syntheses of Heterocycles via Alkyne Cycloadditions Catalyzed by Cyclopentadienylruthenium-Type Complexes
  Yoshihiko Yamamoto
  Heterocycles 2013, 87, 2459-2493.
• Theoretical Study on Ruthenium-Catalyzed Hydrocarboxylative Dimerization of Phenylacetylene with Acetic Acid Leading to (1E,3E)-1,4-Diphenyl-1,3-butadienyl Acetate
  Yoshihiko Yamamoto
  Organometallics 2013, 32, 5201-5211.
• Ruthenium-Catalyzed Transfer-Hydrogenative Cyclization of 1,6-Diynes with Hantzsch 1,4-Dihydropyridine as a H₂ Surrogate
  Yoshihiko Yamamoto, Shota Mori, and Masatoshi Shibuya
  Chem. Eur. J. 2013, 19, 12034-12041.

• 有機ニトロキシルラジカルの反応性制御に基づく効率的アルコール空気酸化反応の開発
  澁谷正俊、岩渕好治
  有機合成化学協会誌 2013, 71, 515−525.
• 銅触媒を用いる有機ボロン酸類の電子欠損性アルキンへの共役付加反応
  山本芳彦
  有機合成化学協会誌 2013, 71, 296−306
  

2012

• Nitroxyl Radical/PhI(OAc)₂: One-Pot Oxidative Cleavage of Vicinal Diols to (Di)Carboxylic Acids
  Masatoshi Shibuya, Takuro Shibuta, Hayato Fukuda, and Yoshiharu Iwabuchi
  Org. Lett. 2012, 14, 5010-5013.
• Organocatalytic One-Pot Oxidative Cleavage of Terminal Diols to Dehomologated Carboxylic Acids
  Masatoshi Shibuya, Ryusuke Doi, Takuro Shibuta, Shun-ichiro Uesugi, and Yoshiharu Iwabuchi
  Org. Lett. 2012, 14, 5006-5009.
• オキソアンモニウム塩の設計に基づく有用酸化反応システムの開発研究
  澁谷正俊
  薬学雑誌 2012, 132, 1131−1143.
• Copper-Catalyzed Regio- and Stereoselective Conjugate Allylation of
  Electron-Deficient Alkynes with Allylboronate under Mild Conditions
  Yoshihiko Yamamoto, Satoshi Yamada, Hisao Nishiyama
  Chem. Eur. J. 2012, 18, 3153-3156.
• Ruthenium-Catalyzed Transfer Oxygenative Cyclization of alpha,omega-Diynes:
  Unprecedented [2+2+1] Route to Bicyclic Furans via Ruthenacyclopentatriene
  Ken Yamashita, Yoshihiko Yamamoto, and Hisao Nishiyama
  J. Am. Chem. Soc. 2012, 134, 7660-7663
• Ruthenium-Catalyzed hydrophosphinylative cyclization of 1,6-diynes.
  Stereoselective synthesis of exocyclic 1,3-dienylphosphine oxides
  Yoshihiko Yamamoto, Kosuke Fukatsu, Hisao Nishiyama
  Chem. Commun. 2012, 48, 7985-7987.
• Transition-Metal-Catalyzed Cycloisomerizations of alpha, omega-Dienes
  Yoshihiko Yamamoto
  Chem. Rev. 2012, 112, 4736-4769.

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