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Laboratory of Molecular Microbiology,Nagoya University

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  • Ohtsuka, H., Kawai S, Otsubo, Y., Shimasaki, T., Yamashita, A., and Aiba, H. Metarhizium robertsii COH1 functionally complements Schizosaccharomyces pombe Ecl family proteins. The Journal of General and Applied Microbiology (2023) DOI:10.2323/jgam.2023.09.001
  • Ohtsuka, H., Sakata, H., Kitazaki, Y., Tada, M. Shimasaki, T., Otsubo, Y., Maekawa, Y., Kobayashi, M., Inada, K., Yamashita, A., and Aiba, H. The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast. Journal of Cell Science (2023) DOI: 10.1242/jcs.260759
  • Maruyama, T., Hayashi, K., Matsui, K., Maekawa, Y., Shimasaki, T., Ohtsuka, H., Saitoh, S., and Aiba, H. Characterization of hexose transporter genes in the views of the chronological life span and glucose uptake in fission yeast. The Journal of General and Applied Microbiology (2022) DOI: 10.2323/jgram.2022.05.006
  • Ohtsuka, H., Hatta, Y., Hayashi, K., Shimasaki, T., Otsubo, Y., Ito, Y., Tsutsui, Y., Hattori, N., Yamashita, A., Murakami, H., and Aiba, H. Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast. Autophagy Reports (2022) DOI: 10.1080/27694127.2022.2047442
  • Ohtsuka, H., Matsumoto, T., Mochida, T., Shimasaki, T., Shibuya, M., Yamamoto, Y., and Aiba, H. Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast. Biosci. Biotech. Biochem. (2022) DOI: 10.1093/bbb/zbac051
  • Matsui, K., Okamoto, K., Hasegawa, T., Ohtsuka, H., Shimasaki, T., Ihara, K., Goto, Y., Aoki, K., and Aiba, H. Identification of ksg1 mutation showing long-lived phenotype in fission yeast. Genes to Cells (2021) DOI: 10.1111/gtc.12897
  • Kurauchi, T. *, Matsui, K. *, Shimasaki, T., Ohtsuka, H., Tsubouchi, S., Ihara, K., Tani, M., and Aiba, H. Identification of sur2 mutation affecting the lifespan of fission yeast. FEMS Microbiology Letters, Volume 368, Issue 12. (2021)
  • Ohtsuka, H., Kobayashi, M., Shimasaki, T., Sato, T., Akanuma, G., Kitaura, Y., Otsubo, Y., Yamashita, A., and Aiba, H. Magnesium depletion extends fission yeast lifespan via general amino acid control activation. MicrobiologyOpen, 10:e1176 (2021)
  • Shimasaki, T., Okamoto, K., Ohtsuka, H., and Aiba, H. Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast. Genes to Cells 25, 825-830 (2020)
  • Imai, Y.*, Shimasaki, T.*, Enokimura, C., Ohtsuka, H., Tsubouchi, S., Ihara, K., and Aiba, H. gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe. Biosci. Biotech. Biochem, 330-337 (2020)
  • Ohtsuka, H*. Kato, T*, Sato, T., Shimasaki, T., Kojima, T., and Aiba, H. Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1. Mol. Genet. Genomics 294, 1499-1509 (2019)
  • Hibi, T.*, Ohtsuka, H.*, Shimasaki, T., Inui, S., Shibuya, M., Tatsukawa, H., Kanie, K., Yamamoto, Y., and Aiba, H. Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway. Genes to Cells 23, 620-637 (2018)
  • Ohtsuka, H., and Aiba, H. Factors extending the chronological lifespan of yeast: Ecl1 family genes. (Review). FEMS Yeast Research. (2017) Nov 1;17(7).
  • Ohtsuka, H.*, Takinami, M.*, Shimasaki, T., Hibi, T., Murakami, H., and Aiba, H. Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. Molecular Microbiology 105, 84-97 (2017)
  • Shimasaki, T., Ohtsuka, H., Naito, C., Azuma, K., Tenno, T., Hiroaki, H., Murakami, H., and Aiba, H. Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological lifespan in fission yeast. Mol. Genet. Genomics 292, 475-481 (2017)
  • Kurauchi, T.*, Hashizume, A.*, Imai, Y., Hayashi K., Tsubouchi, S., Ihara, K., Ohtsuka, H., and Aiba, H. Identification of a novel protein kinase that affects on the chronological lifespan in fission yeast. FEMS Microbiology Letters 364:fnw257 (2017)
  • Hori, M.*, Oka, S*., Sugie, Y., Ohtsuka, H., and Aiba, H. Construction of a photo-responsive chimeric histidine kinase in Escherichia coli. J. Gen. Appl. Microbiol. 63, 44-50 (2017)
  • Sugie, Y.*, Hori, M.*, Oka, S., Ohtsuka, H., and Aiba, H. Reconstruction of a chromatic response system in Escherichia coli. J. Gen. Appl. Microbiol. 62, 140-143 (2016)
  • Ohtsuka, H.*, Ishida, M.*, Naito, C., Murakami, H., and Aiba, H. Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. Mol. Genet. Genomics 290(1), 173-185 (2015)
  • Naito, C., Ito, H., Oshiro., Ohtsuka, H., Murakami, H., and Aiba, H. A new pma1 mutation identified in a chronologically long-lived fission yeast mutant. FEBS Open Bio 4, 829-833 (2014)
  • Murakami-Tonami, Y. *, Ohtsuka, H. *, Aiba, H., and Murakami, H. Regulation of wee1+ expression during meiosis in fission yeast. Cell Cycle 13:18, 2853-2858 (2014)
  • Shimasaki, T. *, Ohtsuka, H. *, Naito, C., Murakami, H., and Aiba, H. Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe. Mol. Genet. Genomics 289(4), 685-693 (2014) Published online: 03 April
  • Ohtsuka, H. *, Ogawa, S. *, Kawamura, H., Sakai, E., Ichinose, K., Murakami, H., and Aiba, H. Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe. Mol. Genet. Genomics 288(5), 285-295 (2013)
  • Takuma, K. *, Ohtsuka, H. *, Azuma, K., Murakami, H. and Aiba, H. The fission yeast php2 mutant displays a lengthened chronological lifespan. Biosci. Biotech. Biochem. 77(7), 1548-1555 (2013)
  • Azuma, K., Ohtsuka, H., Murakami, H. and Aiba, H. Extension of chronological lifespan by ScEcl1 depends on mitochondria in Saccharomyces cerevisiae. Biosci. Biotech. Biochem. 76(10), 1938-1942 (2012)
  • Murakami, H. and Aiba, H. Another way to induce synchronous meiosis. Cell Cycle 11(10), 1874-1875 (2012)
  • Ohtsuka, H., Azuma, K., Kubota, S., Murakami, H., Giga-Hama, Y., Tohda, H. and Aiba, H. Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast. Genes to Cells. 17. 39-52 (2012)
  • Miwa, Y. *, Ohtsuka, H. *, Naito, C., Murakami, H. and Aiba, H. Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation. Biosci. Biotech. Biochem. 75. 279-283 (2011)
  • Ohtsuka, H., Azuma, K., Murakami, H., and Aiba, H. hsf1+ extends chronological lifespan through Ecl1 family genes in fission yeast. Mol. Genet. Genomics 285. 67-77 (2011)
  • Murakami, H., Aiba, H., Nakanishi, M. and Murakami-Tonami, Y. Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and Polo-like kinases. Cell Cycle 9 (16), 3233-3242 (2010)
  • Ito, H., Oshiro, T., Fujita, Y., Kubota, S., Naito, C., Ohtsuka, H., Murakami, H., and Aiba, H. Pma1, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast. J. Biol. Chem. 285. 34616-34620 (2010)
  • Azuma, K., Ohtsuka, H., Mita, S., Murakami, H., and Aiba, H. Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae. Biosci. Biotech. Biochem. 73. 2787-2789 (2009)
  • Ito. T., Uozumi, N., Nakamura, T., Takayama, S., Matsuda, N., Aiba, H., Hemmi, H., and Yoshimura, T. The implication of YggT of Escherichia coli in osmotic regulation. Biosci. Biotech. Biochem. 73. 2698-2704 (2009)
  • Shimada, M., Yamamoto, A., Murakami-Tonami, Y., Nakanishi, M., Yoshida, T., Aiba, H., and Murakami, H. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Biochem. Biophy. Res. Com. 388. 529-532. (2009)
  • Ohtsuka, H., Ogawa, Y., Mizuno H., Mita, S., and Aiba, H. Identification of Ecl family genes that extend chronological lifespan in fission yeast. Biosci. Biotech. Biochem. 73. 885-889. (2009)
  • Ohtsuka, H., Mita, S., Ogawa, Y., Azuma, K., Ito, H., and Aiba, H. A novel gene, ecl1+, extends chronological lifespan in fission yeast. FEMS Yeast Research 8. 520-530 (2008)
  • Fujita, Y. *, Mita, S. *, Ohtsuka, H., and Aiba, H. Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affect viability after entry into the stationary phase in Schizosaccharomyces pombe. Biosci. Biotech. Biochem. 71. 3041-3047. (2007)
  • Kato, Y., Sugiura, M., Mizuno, T., and Aiba, H. Effect of the arcA mutation on the expression of flagella genes in Escherichia coli. Biosci. Biotech. Biochem. 71. 77-83. (2007)
  • Grainger, D., Aiba, H., Hurd, D,. Browning, D., and Busby, S. Transcription factor distribution in Escherichia coli: studies with FNR protein. Nucleic Acids Research. 35. 269-278. (2007)
  • Oshima, T., Ishikawa, S., Kurokawa, K., Aiba, H., and Ogasawara, N. Escherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymerase. DNA Research 13. 141-153. (2006)
  • Yamamoto, K., Hirao, K., Oshima, T., Aiba, H., Utsumi, R., and Ishihama, A. Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli. J. Biol. Chem. 280. 1448-1456. (2005)
  • Hagiwara, D., Sugiura, M., Oshima, T., Mori, H., Aiba, H., Yamashino, T., and Mizuno, T. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. J. Bacteriol. 185. 5735-5746. (2003)
  • Sugiura, M., Aiba, H., and Mizuno, T. Identification and classification of two-component systems that affect rpoS expression in Escherichia coli. Biosci. Biotech. Biochem. 67. 1612-1615. (2003)
  • Oshiro, T., Aiba, H., and Mizuno, T. A defect in a fatty acyl-CoA synthetase gene, lcf1+, results in a decrease in viability after entry into the stationary phase in fission yeast. Mol. Genet. Genomics. 269. 437-442. (2003)
  • Nakamichi, N., Yamada, H., Aiba, H., Aoyama, K., Ohmiya, R., and Mizuno, T. Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe. Biosci. Biotech. Biochem. 67. 547-555. (2003)
  • Nakamichi, N., Yamada, H., Aoyama, K., Ohmiya, R., Aiba, H., and Mizuno, T. His-to-Asp phosphorelay circuitry for regulation of sexual development in Schizosaccharomyces pombe. Biosci. Biotech. Biochem. 66. 2663-2672. (2002)
  • Oshima, T., Aiba, H., Masuda, Y., Kanaya, S., Sugiura, M., Wanner, B. L., Mori, H., and Mizuno, T. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Mol. Microbiol. 46. 281-291. (2002)
  • Aoyama, K., Aiba, H., and Mizuno, T. Genetic analysis of the His-to-Asp phosphorelay implicated in mitotic cell cycle control: Involvement of histidine-kinase genes of Schizosaccharomyces pombe. Biosci. Biotech. Biochem. 65. 2347-2352. (2001)
  • Takeda, S., Fujisawa, Y., Matsubara, M., Aiba, H., and Mizuno, T. A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC --> YojN --> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol. Microbiol. 40. 440-450. (2001)
  • Suzuki, T., Miwa, K., Ishikawa, K., Yamada, H., Aiba, H., and Mizuno, T. The Arabidopsis sensor His-kinase, AHK4, can respond to cytokinins. Plant Cell Physiol. 42. 107-113. (2001)
  • Ohmiya, R., Yamada, H., Kato, C., Aiba, H., and Mizuno, T. The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast. Mol. Gen. Genet. 264. 441-451. (2000)
  • Nakamichi, N., Yamamoto, E., Yamada, H., Aiba, H., and Mizuno, T. Identification and characterization of a novel gene, hos2+, the function of which is necessary for growth under high osmotic stress in fission yeast. Biosci. Biotech. Biochem. 64. 2493-2496. (2000)
  • Aoyama, K., Mitsubayashi, Y., Aiba, H., and Mizuno, T. Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator. J. Bacteriol. 182. 4868-4874. (2000)
  • Aoyama, K., Kawaura, R., Yamada, H., Aiba, H., and Mizuno, T. Identification and characterization of a novel gene, hos3+, the function of which is necessary for growth under high osmotic stress in fission yeast. Biosci. Biotech. Biochem. 64. 1099-1102. (2000)
  • Nishikawa, T., Aiba, H., and Mizuno, T. The cta3+ gene that encodes a cation-transporting P-type ATPase is induced by salt stress under control of the Wis1-Sty1 MAPKK-MAPK cascade in fission yeast. FEBS Lett. 455. 183-187. (1999)
  • Ohmiya, R., Kato, C., Yamada, H., Aiba, H., and Mizuno, T. A fission yeast gene (prr1+) that encodes a response regulator implicated in oxidative stress response. J. Biochem. 125. 1061-1066. (1999)
  • Ohmiya, R., Kato, C., Yamada, H., Aiba, H., and Mizuno, T. Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Mol. Gen. Genet. 261. 297-306. (1999)
  • Aiba, H., Kawaura, R., Yamamoto, E., Yamada, H., Takegawa, K., and Mizuno, T. Isolation and characterization of high osmolarity sensitive mutants of fission yeast. J. Bacteriol. 180. 5038-5043. (1998)
  • Falkner, R., Wagner, F., Aiba, H., and Falkner, G. Phosphate-uptake behaviour of a mutant of Synechococcus sp. PCC7942 lacking one protein of the high-affinity phosphate-uptake system. Planta 206. 461-465. (1998)
  • Yamada, H., Ohmiya, R., Yamamoto, E., Aiba, H., and Mizuno, T. Characterization of multicopy suppressor genes that complement a defect in the Wis1-Sty1 MAP kinase cascade involved in stress responses in Schizosaccharomyces pombe. J. Gen. Appl. Microbiol. 43. 209-215. (1997)
  • Ohmiya, R., Aiba, H., Yamada, H., and Mizuno, T. Clarification of the promoter structure of the osmoregulated gpd1+ gene encoding an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast. Biosci. Biotech. Biochem. 61. 553-555. (1997)
  • Hirokawa, K., Ogino, T., Aiba, H., and Mizuno, T. A novel gene that interferes with the phosphotransfer signal transduction mediated by the EnvZ osmosensor in Escherichia coli . Biosci. Biotech. Biochem. 60. 1681-1685. (1996)
  • Umeda, H., Aiba, H., and Mizuno, T. somA, a novel gene that encodes a major outer-membrane protein of Synechococcus sp. PCC7942. Microbiology 142. 2121-2128. (1996)
  • Kato, N., Aiba, H., and Mizuno, T. Suppressor mutations in a-subunit of RNA polymerase for a mutant of the positive regulator, OmpR, in Escherichia coli . FEMS Microbiol. Lett. 139. 175-180. (1996)
  • Yamada, H., Ohmiya, R., Aiba, H., and Mizuno, T. Construction and characterization of a deletion mutant of gpd2 that encodes an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast. Biosci. Biotech. Biochem. 60. 918-920. (1996)
  • Hirokawa, K., Nagaya, M., Aiba, H., and Mizuno, T. A cyanobacterial gene that interferes with the phosphotransfer signal transduction involved in the osmoregulatory expression of ompC and ompF in Escherichia coli . Biosci. Biotech. Biochem. 60. 277-283. (1996)
  • Ohmiya, R., Yamada, H., Nakashima, K., Aiba, H., and Mizuno, T. Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth. Mol. Microbiol. 18. 963-973. (1995)
  • Aiba, H., Yamada, H., Ohmiya, R., and Mizuno, T. The osmo-inducible gpd1+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast. FEBS Lett. 376. 199-201. (1995)
  • Kato, N., Tsuzuki, M., Aiba, H., and Mizuno, T. Gene activation by the Escherichia coli positive regulator OmpR: a mutational study of the DNA-binding domain of OmpR. Mol. Gen. Genet. 248. 399-406. (1995)
  • Tsuzuki, M., Aiba, H., and Mizuno, T. Gene activation by the Escherichia coli positive regulator, OmpR: phosphorylation-independent mechanism of activation by an OmpR mutant. J. Mol. Biol. 242. 607-613. (1994)
  • Aiba, H., Kato, N., Tsuzuki, M., and Mizuno, T. Mechanism of gene activation by the Escherichia coli positive regulator, OmpR: a mutant defective in transcriptional activation. FEBS Lett. 351. 303-307. (1994)
  • Aiba, H., and Mizuno, T. A novel gene whose expression is regulated by the response-regulator, SphR, in response to phosphate limitation in Synechococcus species PCC7942. Mol. Microbiol. 13. 25-34. (1994)
  • Nagaya, M., Aiba, H., and Mizuno, T. The sphR product, a two-component system response regulator protein, regulates phosphate assimilation in Synechococcus sp. strain PCC7942 by binding to two sites upstream from the phoA promoter. J. Bacteriol. 176. 2210-2215. (1994)
  • Nagaya, M., Aiba, H., and Mizuno, T. A cyanobacterial gene encoding a protein with extensive homology to mammalian phosphoribosylpyrophosphate synthetase. Biosci. Biotech. Biochem. 57. 1958-1959. (1993)
  • Nagaya, M., Aiba, H., and Mizuno, T. Cloning of sensory-kinase-encoding gene that belongs to the two-component regulatory family from the cyanobacterium Synechococcus sp. PCC7942. Gene 131. 119-124. (1993)
  • Higashitani, A., Nishimura, Y., Hara, H., Aiba, H., Mizuno, T., and Horiuchi, K. Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli . Mol. Gen. Genet. 240. 339-347. (1993)
  • Aiba, H., Nagaya, M., and Mizuno, T. Sensor and regulator proteins from the cyanobacterium Synechococcus species PCC7942 that belong to the bacterial signal-transduction protein families: implication in the adaptive response to phosphate limitation. Mol. Microbiol. 8. 81-91. (1993)
  • Nagasawa, S., Tokishita, S., Aiba, H., and Mizuno, T. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli . Mol. Microbiol. 6. 799-807. (1992)
  • Igarashi, K., Hanamura, A., Makino, K., Aiba, H., Aiba, Hiroji, Mizuno, T., Nakata, A., and Ishihama, A. Functional map of the a subunit of Escherichia coli RNA polymerase: two modes of transcription activation by positive factors. Proc. Natl. Acad. Sci. USA 88. 8958-8962. (1991)
  • Nakashima, K., Kanamaru, K., Aiba, H., and Mizuno, T. Osmoregulatory expression of the porin genes in Escherichia coli : evidence for signal titration in the signal transduction through EnvZ-OmpR phosphotransfer. FEMS Microbiol. Lett. 82. 43-48. (1991)
  • Tokishita, S., Kojima, A., Aiba, H., and Mizuno, T. Transmembrane signal transduction and osmoregulation in Escherichia coli : functional importance of the periplasmic domain of the membrane-located protein kinase, EnvZ. J. Biol. Chem. 266. 6780-6785. (1991)
  • Nakashima, K., Kanamaru, K., Aiba, H., and Mizuno, T. Signal transduction and osmoregulation in Escherichia coli : a novel type of mutation in the phosphorylation domain of the activator protein, OmpR, results in a defect in its phosphorylation-dependent DNA binding. J. Biol. Chem. 266. 10775-10780. (1991)
  • Tokishita, S., Yamada, H., Aiba, H., and Mizuno, T. Transmembrane signal transduction and osmoregulation in Escherichia coli : II. the osmotic sensor, EnvZ, located in the isolated cytoplasmic membrane displays its phosphorylation and dephosphorylation abilities as to the activator protein, OmpR. J. Biochem. 108. 488-493. (1990)
  • Kanamaru, K., Aiba, H., and Mizuno, T. Transmembrane signal transduction and osmoregulation in Escherichia coli : I. analysis by site-directed mutagenesis of the amino acid residues involved in phosphotransfer between the two regulatory components, EnvZ and OmpR. J. Biochem. 108. 483-487. (1990)
  • Aiba, H., and Mizuno, T. Phosphorylation of a bacterial activator protein, OmpR, by a protein kinase, EnvZ, stimulates the transcription of the ompF and ompC genes in Escherichia coli. FEBS Lett. 261. 19-22. (1990)
  • Kanamaru, K., Aiba, H., Mizushima, S., and Mizuno, T. Signal transduction and osmoregulation in Escherichia coli : a single amino acid change in the protein kinase, EnvZ, results in loss of its phosphorylation and dephosphorylation abilities with respect to the activator protein, OmpR. J. Biol. Chem. 264. 21633-21637. (1989)
  • Kato, M., Aiba, H., Tate, S., Nishimura, Y., and Mizuno, T. Location of phosphorylation site and DNA-binding site of a positive regulator, OmpR, involved in activation of the osmoregulatory genes of Escherichia coli. FEBS Lett. 249. 168-172. (1989)
  • Kato, M., Aiba, H., and Mizuno, T. Molecular analysis by deletion and site-directed mutagenesis of the cis-acting upstream sequence involved in activation of the ompF promoter in Escherichia coli. J. Biochem. 105. 341-347. (1989)
  • Aiba, H., Nakasai, F., Mizushima, S., and Mizuno, T. Phosphorylation of a bacterial activator protein, OmpR, by a protein kinase, EnvZ, results in stimulation of its DNA-binding ability. J. Biochem. 106. 5-7. (1989)
  • Aiba, H., Nakasai, F., Mizushima, S., and Mizuno, T. Evidence for the physiological importance of the phosphotransfer between the two regulatory components, EnvZ and OmpR, in osmoregulation in Escherichia coli. J. Biol. Chem. 264. 14090-14094. (1989)
  • Aiba, H., Mizuno, T., and Mizushima, S. Transfer of phosphoryl group between two regulatory proteins involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli. J. Biol. Chem. 264. 8563-8567. (1989)
  • Aiba, H., Matsuyama, S., Mizuno, T., and Mizushima, S. Function of micF as an antisense RNA in osmoregulatory expression of the ompF gene in Escherichia coli. J. Bacteriol. 169. 3007-3012. (1987)
  • Itoh, M., Aiba, H., Inokuchi, K., Mizuno, T., Nagahari, K., Munakata, K., and Mizushima, S. A controllable expression-secretion vector constructed from the multiple trp promoter-operator, the signal peptide region of the ompF gene and the trpR gene in Escherichia coli. Agric. Biol. Chem. 50. 1295-1302. (1986)

分子微生物学分野

〒464-8601    
愛知県名古屋市千種区不老町
名古屋大学大学院 創薬科学研究科
基盤創薬学専攻 創薬生物科学講座
分子微生物学分野