{"id":4429,"date":"2023-11-13T19:33:33","date_gmt":"2023-11-13T10:33:33","guid":{"rendered":"http:\/\/133.6.82.55\/lab_pages\/chemprocess\/?page_id=4429"},"modified":"2026-06-03T15:44:51","modified_gmt":"2026-06-03T07:44:51","slug":"kenkyugyoseki-gencho","status":"publish","type":"page","link":"https:\/\/www.ps.nagoya-u.ac.jp\/lab_pages\/chemprocess\/kenkyugyoseki-gencho\/","title":{"rendered":"\u539f\u8457\u8ad6\u6587 (original papers)"},"content":{"rendered":"\n

 <\/h4>\n

2025 2024<\/span><\/a> 2023<\/span><\/a> 2022<\/span><\/a> 2021<\/span><\/a> 2020<\/a><\/span>  \uff5e2019<\/span><\/a><\/h4>\n\n\n\n

2026

101.\u00a0 A Short Synthesis of Cyclo(-RGDfK) Using a Microflow Reactor
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0N. Yamasaki, M. Kim, K. Miyamoto, Y. Otake, K. Adachi, D. Kubo, S. Fuse
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0ChemistryEurope accepted for publication<\/em>

100.\u00a0\u00a0Stereoselective synthesis of phosphoramidates via sequential nucleophilic
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0attacks by metal amides and alkoxides
\u00a0 \u00a0 \u00a0 \u00a0 Y. Tanaka, T. Murai, S. Fuse
\u00a0 \u00a0 \u00a0 \u00a0\u00a0Commun. Chem. accepted for publication<\/em><\/a><\/span><\/p>\n\n\n\n

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<\/a>2025<\/p>\n\n\n\n

99.  Optimizing microflow sequential coupling and cyclization of multiple linear
        substrates guided by Bayesian optimization
        S. Fuse, K. Nakabayashi, N. Sugisawa, H. Sugisawa, S. Asano, N. Yamasaki
        Bull. Chem. Soc. Jpn. 98,<\/em> (4), uoaf022, (2025).<\/a><\/span>
         published April 15 2025 DOI: 10.1093\/bulcsj\/uoaf022
         Designated as a “Selected Paper”<\/strong><\/span><\/p>\n\n\n\n

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<\/a>2024<\/p>\n\n\n\n

98.  Avoiding undesired intramolecular diketopiperazine formation during
        peptoid chain elongation using a microflow reactor
        Y. Okura, Y. Tanaka, S. Fuse
        Org. Lett. 26,<\/em> (48), 10280-10284, (2024).<\/a><\/span>
<\/span>        published November 19 2024 DOI: 10.1021\/acs.orglett.4c03807
        Highlighted in Synfacts 03\/2025<\/strong><\/p>\n\n\n\n

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97.  Switching between P-acylation and O-acylation of H-phosphonates with
        chloroformates by changing acyl pyridinium and acyl ammonium ions
        in a microflow reactor
        H. Kitamura, Y. Tanaka, S. Fuse
        Chem. Commun. 60,<\/em> 10874, (2024).<\/a><\/span>
<\/em>        published Aug 27 2024 DOI: 10.1039\/D4CC02871F <\/p>\n\n\n\n

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96.  One-step syntheses of diaza-dioxa-fenestranes via the sequential (3+2)
        cycloadditions of linear precursors and their structural analyses
        S. Fuse, H. Ishikawa, H. Kitamura, H. Masui, T. Takahashi
        Nat. Commun.<\/em> 15,<\/em> 6087, (2024).<\/i><\/a><\/span>  
        published Jul 19 2024 DOI: 10.1038\/s41467-024-49935-1<\/p>\n\n\n\n

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95.  Rapid and mild nucleophilic substitution of highly active (indol-2-yl)methyl
        electrophile in a microflow reactor
        S. Fuse, Y. Matsuura, N. Yamasaki
        Synthesis 56, <\/em>(17), 2663-2669, (2024)<\/a><\/span>. 
        published Jun 13 2024 DOI: 10.1055\/s-0043-1775370<\/p>\n\n\n\n

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94.  Effect of Br\u00f8nsted acids on the activation of mixed anhydride\/mixed carbonic
       anhydride and C-terminal-free N<\/em>-methylated peptide synthesis in a micro-flow
       reactor
        T-H. Chen, A. Ando, O. Shamoto, S. Fuse,
        Chem. Eur. J. 30, <\/em>(38), e202401402, (2024).<\/em><\/span><\/a>
        published May 08 2024 DOI: 10.1002\/chem.202401402
        Highlighted in Synfacts<\/em> 09\/2024
        Selected as Synfact of the Month<\/a><\/span><\/strong><\/p>\n\n\n\n

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93. Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and
       nucleophilic addition in a microflow reactor
        Y. Matsuura, S. Fuse,
        Org. Biomol. Chem. 22,<\/em> (17), 3448-3452 (2024).<\/em> <\/a><\/span>
        published Apr. 10 2024 DOI: 10.1039\/D4OB00358F<\/p>\n\n\n\n

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92.  Microflow, sequential coupling and cyclization approach for synthesis
        of cyclic phosphotriesters from PCl3<\/sub>
        K. Nakabayashi, H. Kitamura, S. Fuse
       Chem. Asian J. 19,<\/a><\/span><\/em> (11), e202400256, (2024)<\/a><\/span>.
<\/em>        published Mar. 31 2024 DOI: 10.1002\/asia.202400256<\/p>\n\n\n\n

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91.  Facile generation of t<\/em>-butoxycarbonyl chloride equivalent and its use in
        micro-flow reactor
        K. Miyamoto, R. Okabe, S. Fuse,
       Org. Process Res. Dev. 28,<\/em> (5), 1971-1978 (2024).<\/span><\/a>
        published Apr. 8 2024 DOI: 10.1021\/acs.oprd.4c00009
        Highlighted in Org. Chem. Highlights <\/em> March 31\/2025<\/a><\/span>
<\/strong><\/p>\n\n\n\n

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90.  Micro-flow heteroatom alkylation via TfOH-mediated rapid in situ generation of
       carbocations and subsequent nucleophile addition
        Y. Matsuura, S. Fuse,
        Chem. Commun. 60,<\/em> 2497-2500 (2024).<\/em><\/span><\/a> 
        published Jan. 29 2024 DOI: 10.1039\/D3CC06308A<\/p>\n\n\n\n

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89.  Micro-flow synthesis of unsymmetrical H<\/em>-phosphonates via sequential and
       direct substitution of chlorine atoms in phosphorus trichloride with alkoxy
       groups
        Y. Tanaka, H. Kitamura, S. Fuse,
        J. Org. <\/em>Chem. 89,<\/em> (3), 1777-1783 (2024).<\/a>
        published Jan. 1 2024 DOI: 10.1021\/acs.joc.3c02467<\/span>
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<\/a>2023<\/p>\n\n\n\n

88.  Multi-objective Bayesian optimisation using q-Noisy Expected 
        Hypervolume Improvement (qNEHVI) for Schotten-Baumann reaction
        J. Zhang, N. Sugisawa, K. C. Felton, S. Fuse, A. A. Lapkin,
        React. Chem. Eng. 9 <\/a><\/span><\/em>(3), 706-712, (2024).<\/a><\/span>
<\/em>        published Dec. 1 2023 DOI: 10.1039\/D3RE00502J<\/span><\/span><\/p>\n\n\n\n

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87.  One flow synthesis of substituted indoles via sequential
       1,2-addition\/nucleophilic substitution of indolyl-3-carbaldehydes       
       S. Fuse, S. Kanda, H. Masui,
       Chem. Asian J. 19, <\/span><\/a><\/em>(1), e202300909 (2024).<\/span><\/a>
       published Nov. 14 2023 DOI: 10.1002\/asia.202300909<\/p>\n\n\n\n

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86. Switchable synthesis of 7- and 14-membered cyclic peptides containing
       N<\/em>-methyl- and \u03b2-amino acids utilizing micro-flow technology
       S. Fuse, R. Okabe,
       Eur. J. Org. Chem. 26,<\/em> (35), e202300700 (2023).<\/a><\/span>
<\/em>       published Jul. 18 2023 DOI: 10.1002\/ejoc.202300700<\/p>\n\n\n\n

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85. One-flow syntheses of unsymmetrical sulfamides and N<\/em>-substituted 
      sulfamate esters
      N. Sugisawa, K. Nakabayashi, H. Sugisawa, S. Fuse,
      Org. Lett. 26,<\/em> (14), 2739-2744 (2024).<\/a><\/span>
      <\/em>published Jun. 13 2023 DOI: 10.1021\/acs.orglett.3c01546<\/p>\n\n\n\n

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84.  Rapid and column-chromatography-free peptide chain elongation via a
       one-flow, three-component coupling approach
       N. Sugisawa, A. Ando, S. Fuse,
       Chem. Sci. 14,<\/em> (25), 6986-6991 (2023).<\/a><\/span>
 <\/em>      published Jun. 12 2023 DOI: 10.1039\/D3SC01333B
       Highlighted in <\/strong>Org. Process Res. Dev.<\/em>
<\/strong>       “Some items of interest to process R&D chemists and engineers<\/span><\/a>”        <\/strong>       Highlighted in Synfacts<\/em> 09\/2023
       Selected as Synfact of the Month<\/a><\/span><\/strong><\/p>\n\n\n\n

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83.  Peptide cyclization by the use of acylammonium species
       O. Shamoto, K. Komuro, N. Sugisawa, T-H. Chen, H. Nakamura, S. Fuse,
       Angew. Chem. Int. Ed. 62,<\/em> (27), e202300647, (2023).<\/em><\/a><\/span>
<\/strong>       published May 10 2023 DOI: 10.1002\/anie.202300647
       Highlighted in Synfacts<\/em> 08\/2023
        Selected as Synfact of the Month<\/span><\/a><\/strong>
       \u65e5\u7d4c\u96fb\u5b50\u7248\u63b2\u8f09\uff08\u4ee4\u548c5\u5e745\u670818\u65e5\uff09<\/a>  <\/strong><\/span><\/p>\n\n\n\n

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82.  Verification of the previous synthesis for (1H<\/em>-indol-3-yl)methyl halide and
       development of its rapid generation and nucleophilic substitution method
       H. Masui, S. Kanda, S. Fuse
       Commun. Chem. 6,<\/em> 47, (2023).<\/span><\/a>
       published Mar. 4 2023 DOI: 10.1038\/s42004-023-00837-1
       \u65e5\u520a\u5de5\u696d\u65b0\u805e\u63b2\u8f09\uff08\u4ee4\u548c5\u5e743\u670810\u65e5\uff09<\/strong><\/p>\n\n\n\n

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81.  Liquid-phase continuous-flow peptide synthesizer for preparing C-terminal
       free peptides
       Y. Otake, K. Adachi, Y. Yamashita, N. Iwanaga, H. Sunakawa, T. Shamoto,
        J. Ogawa, A. Ito, Y. Kobayashi, K. Masuya, S. Fuse, D. Kubo, H. Ito
       React. Chem. Eng. 8<\/em> (4) 863-870 (2023).<\/span><\/a>
      published Dec. 16 2022 DOI: 10.1039\/D2RE00453D<\/p>\n\n\n\n

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<\/a>2022<\/strong><\/h4>\n

80.  Sequential nucleophilic substitution of phosphorus trichloride with alcohols in a
       continuous-flow reactor and consideration of a mechanism for reduced
       overreaction via the addition of imidazole
       H. Kitamura, Y. Otake, N. Sugisawa, H. Sugisawa, T. Ida, H. Nakamura, S. Fuse
       Chem. Eur. J. 28,<\/em> (37), e202200932, (2022).<\/span><\/a>
       published Jun. 13 2022 DOI: 10.1002\/chem.202200932
       Highlighted in Synfacts 08\/2022<\/strong>
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79.  Micro-flow rapid dual activation approach for the urethane-protected \u03b1-amino acid
       N<\/em>-carboxy anhydride synthesis,
       R. Okabe, N. Sugisawa, S. Fuse,
       Org. Biomol. Chem. 20,<\/em> (16), 3303-3310, (2022). <\/span><\/a>
       published Mar. 1 2022 DOI: 10.1039\/D2OB00167E
       Highlighted in Synfacts 06\/2022<\/strong>
       Inside Front Cover Picture<\/strong><\/p>\n\n\n\n

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<\/a>2021<\/strong><\/h4>\n

78.  Rapid and mild one-flow synthetic approach to unsymmetrical sulfamides guided by
       Bayesian optimization,
       N. Sugisawa, H. Sugisawa, Y. Otake, R. V. Krems, H. Nakamura, S. Fuse,
       Chem. Methods 1, <\/em>(11), 484-490, (2021). <\/span><\/a>
       published Aug. 18 2021 DOI: 10.1002\/cmtd.202100053
       \u65e5\u520a\u5de5\u696d\u65b0\u805e\u63b2\u8f09\uff08\u4ee4\u548c3\u5e749\u67082\u65e5\uff09<\/strong><\/p>\n\n\n\n

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77.  Rapid and mild lactamization using highly electrophilic triphosgene in
       a micro-flow reactor,
       S. Fuse, K. Komuro, Y. Otake, H. Masui, H. Nakamura,
       Chem. Eur. J. 27, <\/em>(27), 7525-7532 (2021).<\/span><\/a>
       published Jan. 26 2021 DOI: 10.1002\/chem.202100059<\/p>\n\n\n\n

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<\/a>2020<\/strong><\/h4>\n

76.  Size-controllable and scalable production of liposomes using a V-shape 
       mixer micro-flow reactor,
       J. Kawamura, H. Kitamura, Y. Otake, S. Fuse, H. Nakamura,
       <\/em>Org. Process Res. Dev. 24,<\/em> (10), 2122-2127 (2020).<\/a><\/span>
       published Jun. 5 2020 DOI: 10.1021\/acs.oprd.0c00174<\/p>\n\n\n\n

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75. Investigation into the influence of an acrylic acid acceptor in organic 
      D-\u03c0-A sensitizers against phototoxicity
      S. Fuse, W. Moriya, S. Sato, H. Nakamura,
      Bioorg. Med. Chem. 28,<\/em> (13), 115558 (2020).<\/a><\/span>
      published May 19 2020 DOI: 10.1016\/j.bmc.2020.115558<\/p>\n\n\n\n

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74. Photochemical conversion of isoxazoles to 5-hydroxyimidazolines
      T. Morita, S. Fuse, H. Nakamura
      Org. Lett. 22,<\/em> (9), 3460-3463 (2020).<\/a><\/span>
      published Apr. 14 2020 DOI: 10.1021\/acs.orglett.0c00910<\/p>\n\n\n\n

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73. N<\/em>-Methylated peptide synthesis via acyl N<\/em>-methylimidazolium cation
      generation accelerated by a Br\u00f8nsted acid
      Y. Otake, Y. Shibata, Y. Hayashi, S. Kawauchi, H. Nakamura, S. Fuse,
      Angew. Chem. Int. Ed. 59, <\/em>(31), 12925-12930 (2020).<\/span><\/a>
      published Apr. 9 2020 DOI: 10.1002\/anie.202002106
      Highlighted in Synfacts<\/em> 07\/2020
      Selected as Synfact of the Month<\/a><\/span>
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72. Micro-flow synthesis of \u03b2-amino acid derivatives via a rapid dual
      activation approach,
      N. Sugisawa, H. Nakamura, S. Fuse,
      Chem. Commun. 56,<\/em> 4527-4530 (2020).<\/a><\/span>
<\/em>      published Apr. 3 2020 DOI: 10.1039\/D0CC01403F
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71. Single-step, rapid, and mild synthesis of \u03b2-amino acid N<\/em>-carboxy
      anhydrides using micro-flow technology,
      N. Sugisawa, Y. Otake, H. Nakamura, S. Fuse,
      Chem. Asian J. 15, <\/em>(1), 79-84 (2020).<\/span><\/a>
      published Nov. 28 2019 DOI: 10.1002\/asia.201901429
      This manuscript was also published in
      The special collection for the 100th CSJ Annual Meeting<\/a>.<\/span><\/p>\n\n\n\n

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<\/a>\u540d\u53e4\u5c4b\u5927\u5b66\u5e03\u65bd\u7814\u7a76\u5ba4\u767a\u8db3\u524d\u306e\u539f\u8457\u8ad6\u6587\u30ea\u30b9\u30c8\u306f\u3053\u3061\u3089<\/span><\/a>
Original papers before moving to Nagoya University, see<\/span><\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"  2025 2024 2023 2022 2021 2020  \uff5e2019 2026 101.\u00a0 A Short Synthesis of Cyclo(-RGDfK) Using a Mi […]

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